甲状腺功能亢进和甲状腺功能减退对大鼠骨骼肌谷氨酰胺代谢的影响。
Effects of hyperthyroidism and hypothyroidism on glutamine metabolism by skeletal muscle of the rat.
作者信息
Parry-Billings M, Dimitriadis G D, Leighton B, Bond J, Bevan S J, Opara E, Newsholme E A
机构信息
Cellular Nutrition Research Group, University of Oxford, U.K.
出版信息
Biochem J. 1990 Dec 1;272(2):319-22. doi: 10.1042/bj2720319.
Abstract
- The effects of hyperthyroidism and hypothyroidism on the concentrations of glutamine and other amino acids in the muscle and plasma and on the rates of glutamine and alanine release from incubated isolated stripped soleus muscle of the rat were investigated. 2. Hyperthyroidism decreased the concentration of glutamine in soleus muscle but was without effect on that in the gastrocnemius muscle or in the plasma. Hyperthyroidism also increased markedly the rate of release of glutamine from the incubated soleus muscle. 3. Hypothyroidism decreased the concentrations of glutamine in the gastrocnemius muscle and plasma but was without effect on that in soleus muscle. Hypothyroidism also decreased markedly the rate of glutamine release from the incubated soleus muscle. 4. Thyroid status was found to have marked effects on the rate of glutamine release by skeletal muscle per se, and may be important in the control of this process in both physiological and pathological conditions.
摘要
- 研究了甲状腺功能亢进和甲状腺功能减退对大鼠肌肉和血浆中谷氨酰胺及其他氨基酸浓度的影响，以及对孵育的离体分离比目鱼肌中谷氨酰胺和丙氨酸释放速率的影响。2. 甲状腺功能亢进降低了比目鱼肌中谷氨酰胺的浓度，但对腓肠肌或血浆中的谷氨酰胺浓度没有影响。甲状腺功能亢进还显著增加了孵育的比目鱼肌中谷氨酰胺的释放速率。3. 甲状腺功能减退降低了腓肠肌和血浆中谷氨酰胺的浓度，但对比目鱼肌中的谷氨酰胺浓度没有影响。甲状腺功能减退还显著降低了孵育的比目鱼肌中谷氨酰胺的释放速率。4. 发现甲状腺状态对骨骼肌本身的谷氨酰胺释放速率有显著影响，在生理和病理条件下对这一过程的控制可能都很重要。
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