在国家糖尿病、内分泌与遗传学中心（NCDEG）就诊的肥胖2型糖尿病患者中低镁血症的患病率。
Prevalence of Hypomagnesaemia among Obese Type 2 Diabetic Patients Attending the National Center for Diabetes, Endocrinology and Genetics (NCDEG).
作者信息
Hyassat Dana, Al Sitri Ebtihaj, Batieha Anwar, El-Khateeb Mohammed, Ajlouni Kamel
机构信息
The National Center for Diabetes, Endocrinology and Genetics Center, Amman, Jordan.
Jordan University of Science and Technology (JUST), Amman, Jordan.
出版信息
Int J Endocrinol Metab. 2014 Jul 1;12(3):e17796. doi: 10.5812/ijem.17796. eCollection 2014 Jul.
BACKGROUND
Some observations suggested that magnesium supplementation could be helpful in the treatment of diabetic patients by improving glycemic control and preventing the development of diabetes-related complications.
OBJECTIVES
To estimate the prevalence of hypomagnesaemia among obese patients with type 2 diabetes attending the National Center for Diabetes, Endocrinology and Genetics (NCDEG) in Amman, Jordan.
PATIENTS AND METHODS
A cross-sectional study was carried out at the National Center for diabetes, Endocrinology and Genetics (NCDEG) in Amman-Jordan. A total of 1105 patients with type 2 diabetes (51.9% females and 48.1% males) who attended this center between first of October 2011and end of February 2012 were included in the study. The mean age and duration of diabetes were 57.1 years and 5.1 years, respectively and the mean value of HbA1c was 7.9%. Our study also performed a comparison of the prevalence of hypomagnesaemia between our studied sample and 3600 individuals enrolled in the National Vitamin D study completed in Jordan in 2009. The obtained data included patients' age, gender, smoking history, HbA1c level, comorbid history including hypertension, dyslipidemia, and presence of neuropathy and retinopathy.
RESULTS
Out of 1105 patients with type 2 diabetes, 210 patients (19%) (95% CI, 16.8%-21.4%) were hypomagnesaemic. Female gender, hypertension, statin therapy, HbA1c between 7-7.9% or ≥ 9% and patients with diabetes duration more than five years were independent risk factors for hypomagnesaemia. No association between hypomagnesaemia and age distribution, smoking history, neuropathy and retinopathy was found. In comparison with individuals enrolled in the National Vitamin D study, diabetic patients in this study had a much higher prevalence of hypomagnesaemia (19% vs. 0.7%) with odd's ratio of 32 (95% CI, 21-48.2).
CONCLUSIONS
As the prevalence of hypomagnesaemia among patients with type 2 diabetes treated at the NCDEG was found to be 19% (95% CI, 16.8%-21.4%), we recommend periodic determination of magnesium level and appropriate magnesium replacement therapy particularly among the above defined groups.
背景
一些观察结果表明，补充镁可能有助于治疗糖尿病患者，改善血糖控制并预防糖尿病相关并发症的发生。
目的
评估约旦安曼国家糖尿病、内分泌与遗传学中心（NCDEG）就诊的肥胖2型糖尿病患者中低镁血症的患病率。
患者与方法
在约旦安曼的国家糖尿病、内分泌与遗传学中心（NCDEG）开展了一项横断面研究。纳入了2011年10月1日至2012年2月底期间在该中心就诊的1105例2型糖尿病患者（女性占51.9%，男性占48.1%）。糖尿病的平均年龄和病程分别为57.1岁和5.1年，糖化血红蛋白（HbA1c）的平均值为7.9%。我们的研究还比较了研究样本与2009年在约旦完成的国家维生素D研究中纳入的3600名个体的低镁血症患病率。获得的数据包括患者的年龄、性别、吸烟史、HbA1c水平、合并症史，包括高血压、血脂异常以及神经病变和视网膜病变情况。
结果
在1105例2型糖尿病患者中，210例（19%）（95%CI，16.8%-21.4%）为低镁血症患者。女性、高血压、他汀类药物治疗、HbA1c在7%-7.9%或≥9%以及糖尿病病程超过5年的患者是低镁血症的独立危险因素。未发现低镁血症与年龄分布、吸烟史、神经病变和视网膜病变之间存在关联。与国家维生素D研究中纳入的个体相比，本研究中的糖尿病患者低镁血症患病率更高（19%对0.7%），优势比为32（95%CI，21-48.2）。
结论
由于在NCDEG接受治疗的2型糖尿病患者中低镁血症患病率为19%（95%CI，16.8%-21.4%），我们建议定期测定镁水平并进行适当的镁替代治疗，尤其是在上述定义的人群中。
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