Zhang Jingxin, Zhang Binjing, Zhang Jinglan, Lin Weimin, Zhang Shiwen
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Cell Dev Biol. 2021 Aug 11;9:717854. doi: 10.3389/fcell.2021.717854. eCollection 2021.
Peripheral nerve injury is a common complication in trauma, and regeneration and function recovery are clinical challenges. It is indispensable to find a suitable material to promote peripheral nerve regeneration due to the limited capacity of peripheral nerve regeneration, which is not an easy task to design a material with good biocompatibility, appropriate degradability. Magnesium has captured increasing attention during the past years as suitable materials. However, there are little types of research on magnesium promoting peripheral nerve regeneration. In this review, we conclude the possible mechanism of magnesium ion promoting peripheral nerve regeneration and the properties and application of different kinds of magnesium-based biomaterials, such as magnesium filaments, magnesium alloys, and others, in which we found some shortcomings and challenges. So, magnesium can promote peripheral nerve regeneration with both challenge and potential.
周围神经损伤是创伤中常见的并发症，其再生和功能恢复是临床面临的挑战。由于周围神经再生能力有限，寻找合适的材料促进周围神经再生至关重要，而设计具有良好生物相容性和适当降解性的材料并非易事。近年来，镁作为合适的材料受到越来越多的关注。然而，关于镁促进周围神经再生的研究类型较少。在本综述中，我们总结了镁离子促进周围神经再生的可能机制以及不同种类镁基生物材料（如镁丝、镁合金等）的性能和应用，其中我们发现了一些缺点和挑战。因此，镁促进周围神经再生既具有挑战性又具有潜力。
