伊朗北部阿莫勒地区基于人群的乙型肝炎病毒研究。
A population based study on hepatitis B virus in northern iran, amol.
作者信息
Keyvani Hossein, Sohrabi Masoudreza, Zamani Farhad, Poustchi Hossein, Ashrafi Hossein, Saeedian Fatemeh, Mooadi Mansooreh, Motamed Nima, Ajdarkosh Hossein, Khonsari Mahmoodreza, Hemmasi Gholamreza, Ameli Mitra, Kabir Ali, Khodadost Mahmoud
机构信息
Department of Virology, Iran University of Medical Sciences, Tehran, IR Iran.
Gastrointestinal and Liver Diseases Research Center (GILDRC), Iran University of Medical Sciences, Tehran, IR Iran.
出版信息
Hepat Mon. 2014 Aug 17;14(8):e20540. doi: 10.5812/hepatmon.20540. eCollection 2014 Aug.
BACKGROUND
Viral hepatitis is a major health problem worldwide. Change in transmission patterns of hepatitis B makes it necessary to re-evaluate its prevalence and risk factors.
OBJECTIVES
We aimed to determine the prevalence of HBV infection and its related risk factors in Amol city, Northern Iran.
PATIENTS AND METHODS
As a population based study, a cluster sampling approach was used and 6146 individuals from the general population of urban and rural areas of Amol, Iran, from both genders and different ages were enrolled. Inclusion criteria were willingness to participate in the study, being a lifelong resident in Amol city or its surrounding areas with Iranian nationality. Ten milliliters (10 mL) of blood was taken from each study subject and checked regarding hepatitis B markers including HbsAg, HBsAb and HBcAb using a third generation ELISA. The prevalence of HBV infections and its potential risk factors were recorded.
RESULTS
The prevalence of HBsAg, HBsAb and HBcAb were estimated as 0.9%, 30.7% and 10.5%, respectively. The mean age of all participants was 43.9 (95% CI: 43.4, 44.3) in females and 55.6 in (n = 3472) males. In our study, there was a significant association between family history of hepatitis, rural residency and presence of HBsAg. There was also a positive correlation between HBcAb and family history of hepatitis, history of other types of hepatic diseases, history of tattooing, traditional phlebotomy, male gender and age. In backward logistic regression, a significant association was found between history of hepatitis in first-degree family members (OR = 13.35; 95% CI: 6.26, 28.47) and place of residence (OR = 2.32; 95% CI: 1.27, 4.22) with presence of HBsAg. There was also a positive correlation between history of hepatitis among first-degree family members (OR = 2.49; 95% CI: 1.52, 4.08), history of tattooing (OR = 2.13; 95% CI: 1.33, 3.42), history of previous hepatitis (OR = 1.87; 95% CI: 1.06, 3.28), male sex (OR = 1.36; 95% CI: 1.12, 1.66) and age (OR = 1.03; 95% CI: 1.03, 1.04) with presence of HBcAb.
CONCLUSIONS
The prevalence of hepatitis B in Amol City and its surrounding areas was about one percent, a lower rate than other reports from Iran.
背景
病毒性肝炎是全球主要的健康问题。乙型肝炎传播模式的变化使得有必要重新评估其流行率和风险因素。
目的
我们旨在确定伊朗北部阿莫勒市乙肝病毒（HBV）感染的流行率及其相关风险因素。
患者和方法
作为一项基于人群的研究，采用整群抽样方法，纳入了来自伊朗阿莫勒市城乡地区、不同性别和年龄的6146名普通人群。纳入标准为愿意参与研究、为阿莫勒市或其周边地区的终身居民且具有伊朗国籍。从每位研究对象采集10毫升血液，使用第三代酶联免疫吸附测定法（ELISA）检测乙肝标志物，包括乙肝表面抗原（HbsAg）、乙肝表面抗体（HBsAb）和乙肝核心抗体（HBcAb）。记录HBV感染的流行率及其潜在风险因素。
结果
HbsAg、HBsAb和HBcAb的流行率分别估计为0.9%、30.7%和10.5%。所有参与者的平均年龄在女性中为43.9岁（95%置信区间：43.4，44.3），在男性（n = 3472）中为55.6岁。在我们的研究中，肝炎家族史、农村居住情况与HbsAg的存在之间存在显著关联。HBcAb与肝炎家族史、其他类型肝病病史、纹身史、传统静脉切开术史、男性性别和年龄之间也存在正相关。在向后逻辑回归分析中，发现一级家庭成员的肝炎病史（比值比[OR] = 13.35；95%置信区间：6.26，28.47）和居住地点（OR = 2.32；95%置信区间：1.27，4.22）与HbsAg的存在之间存在显著关联。一级家庭成员的肝炎病史（OR = 2.49；95%置信区间：1.52，4.08）、纹身史（OR = 2.13；%置信区间：1.33，3.42）、既往肝炎病史（OR = 1.87；95%置信区间：1.06，3.28）、男性性别（OR = 1.36；9置信区间：1.12，1.66）和年龄（OR = 1.03；95%置信区间：1.03，1.04）与HBcAb的存在之间也存在正相关。
结论
阿莫勒市及其周边地区的乙肝流行率约为1%，低于伊朗其他报告中的比率。
Zotero 插件