Russo Paul, Mano Roy
Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Korean J Urol. 2014 Sep;55(9):557-67. doi: 10.4111/kju.2014.55.9.557. Epub 2014 Sep 5.
Secondary to the widespread use of the modern imaging techniques of computed tomography, magnetic resonance imaging, and ultrasound, 70% of renal tumors today are detected incidentally with a median tumor size of less than 4 cm. Twenty years ago, all renal tumors, regardless of size were treated with radical nephrectomy (RN). Elective partial nephrectomy (PN) has emerged as the treatment of choice for small renal tumors. The basis of this paradigm shift is three major factors: (1) cancer specific survival is equivalent for T1 tumors (7 cm or less) whether treated by PN or RN; (2) approximately 45% of renal tumors have indolent or benign pathology; and (3) PN prevents or delays the onset of chronic kidney disease, a condition associated with increased cardiovascular morbidity and mortality. Although PN can be technically demanding and associated with potential complications of bleeding, infection, and urinary fistula, the patient derived benefits of this operation far outweigh the risks. We have developed a "mini-flank" open surgical approach that is highly effective and, coupled with rapid recovery postoperative care pathways associated with a 2-day length of hospital stay.
由于计算机断层扫描、磁共振成像和超声等现代成像技术的广泛应用,如今70%的肾肿瘤是偶然发现的,肿瘤中位大小小于4厘米。二十年前,所有肾肿瘤无论大小均采用根治性肾切除术(RN)治疗。选择性部分肾切除术(PN)已成为小肾肿瘤的首选治疗方法。这种范式转变的基础有三个主要因素:(1)对于T1期肿瘤(7厘米或更小),无论采用PN还是RN治疗,癌症特异性生存率相当;(2)约45%的肾肿瘤具有惰性或良性病理特征;(3)PN可预防或延迟慢性肾脏病的发生,慢性肾脏病与心血管发病率和死亡率增加相关。尽管PN在技术上要求较高,且可能伴有出血、感染和尿瘘等潜在并发症,但该手术给患者带来的益处远大于风险。我们开发了一种“小侧腹”开放手术方法,该方法非常有效,再加上与2天住院时间相关的快速康复术后护理路径。