Jeun Minhong, Park Sungwook, Jang Gun Hyuk, Lee Kwan Hyi
Biomedical Research Institute, Korea Institute of Science and Technology (KIST) , Seoul 136-791, Republic of Korea.
ACS Appl Mater Interfaces. 2014 Oct 8;6(19):16487-92. doi: 10.1021/am5057163. Epub 2014 Sep 23.
A superparamagnetic nanoferrite (SPNF) with high magnetic moment, AC magnetically induced heating (AC-heating) capacity, and good biocompatibility is the most vital part of magnetic fluid hyperthermia for utilizing it in the clinics. Herein, we precisely tune magnetic properties and AC-heating characteristics of MgxMn1-xFe2O4 SPNF via chemically controlling the cations' concentration and distribution to develop a tailored MgxMn1-xFe2O4 SPNF as a potential magnetic fluid hyperthermia agent. The magnetic and AC-heating characteristics of the tailored MgxMn1-xFe2O4 SPNF are strongly dependent on the Mg/Mn cations' concentration and distribution, and Mg0.285Mn0.715Fe2O4 SPNF exhibits the highest saturation magnetization and AC-heating capacity as well as high biocompatibility.
具有高磁矩、交流磁致热（交流加热）能力和良好生物相容性的超顺磁性纳米铁氧体（SPNF）是磁流体热疗在临床应用中最重要的部分。在此，我们通过化学控制阳离子的浓度和分布来精确调节MgxMn1-xFe2O4 SPNF的磁性和交流加热特性，以开发一种定制的MgxMn1-xFe2O4 SPNF作为潜在的磁流体热疗剂。定制的MgxMn1-xFe2O4 SPNF的磁性和交流加热特性强烈依赖于Mg/Mn阳离子的浓度和分布，并且Mg0.285Mn0.715Fe2O4 SPNF表现出最高的饱和磁化强度和交流加热能力以及高生物相容性。
