Lim Y J, Kim J S, Im K S, Jung J H, Lee C O, Hong J, Kim D k
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
J Nat Prod. 1999 Sep;62(9):1215-7. doi: 10.1021/np9900371.
New polyacetylenic alcohols with a C(45) carbon skeleton (2) and with an enone moiety in the alkyl chain (C(46), 1) were isolated from the marine sponge Petrosia sp. The gross structures of 1 and 2 were established by spectral methods, and the absolute stereochemistry was determined by the modified Mosher's method. Compounds 1 and 2 displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Significant inhibitions on DNA replication by 1 and 2 were also observed which could be explanative of their cytotoxicity.
从海洋海绵Petrosia sp.中分离出了具有C(45)碳骨架的新型聚乙炔醇（2）以及在烷基链中带有烯酮部分的化合物（C(46)，1）。通过光谱方法确定了1和2的总体结构，并采用改良的莫舍尔方法确定了其绝对立体化学结构。化合物1和2对一小部分人类实体瘤细胞系表现出相当大的细胞毒性。还观察到1和2对DNA复制有显著抑制作用，这可以解释它们的细胞毒性。
