Draganescu D, Ibanescu C, Tamba B I, Andritoiu C V, Dodi G, Popa M I
Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, 700050 Iasi, Romania; Institute of Research and Development in Technical and Natural Sciences, "Aurel Vlaicu" University, 310330 Arad, Romania.
Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, 700050 Iasi, Romania.
Int J Biol Macromol. 2015 Jan;72:614-23. doi: 10.1016/j.ijbiomac.2014.09.012. Epub 2014 Sep 17.
Flaxseed lignans are a natural source of useful biologically active components that show a diverse spectrum of health-promoting properties. The valuable effects of the phenolic molecules are mainly due to their antioxidant activity by preventing oxidative stress and stimulate collagen synthesis, therefore, providing benefits to the skin. The present work highlights the development of flaxseed extract formulation as novel wound healing agent. The recognition of key structural features within flaxseed extract was crucial for the design and development of the therapeutic cream. Chromatographic analyses were employed for bioactive compounds identification and quantification. Folin-Ciocalteu method determined the total phenolic content and the antioxidant properties were evaluated by DPPH assay. The storage and loss modulus and tan δ were calculated for cream rheological properties evaluation. In vitro diffusion capacity and in vivo wound healing activity of phenolic cream were evaluated on Wistar rats. The collective properties and healing effect of the flaxseed suggested wound healing capacity.
亚麻籽木脂素是有用的生物活性成分的天然来源，具有多种促进健康的特性。酚类分子的宝贵作用主要归因于其抗氧化活性，通过防止氧化应激和刺激胶原蛋白合成，从而为皮肤带来益处。目前的工作重点是开发亚麻籽提取物配方作为新型伤口愈合剂。识别亚麻籽提取物中的关键结构特征对于治疗乳膏的设计和开发至关重要。采用色谱分析来鉴定和定量生物活性化合物。福林-西奥尔特法测定总酚含量，并通过DPPH法评估抗氧化性能。计算储存模量、损耗模量和损耗角正切以评估乳膏的流变学性质。在Wistar大鼠上评估了酚类乳膏的体外扩散能力和体内伤口愈合活性。亚麻籽的综合特性和愈合效果表明其具有伤口愈合能力。
