Draganescu Dan, Andritoiu Calin, Hritcu Doina, Dodi Gianina, Popa Marcel Ionel
Faculty of Chemical Engineering and Environmental Protection, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania.
Institute of Research and Development in Technical and Natural Sciences, Aurel Vlaicu University, 310025 Arad, Romania.
Biology (Basel). 2021 Jan 11;10(1):43. doi: 10.3390/biology10010043.
Flaxseeds play an important role in human health due to their chemical composition and recognized beneficial outcomes. This study investigated the antidiabetic effects of present lignans and polyphenols found in the flaxseed extract on streptozotocin (STZ)-induced diabetic rats. The flaxseed administration produced favorable changes in body weight, food and water intake, and glycosylated hemoglobin and blood glucose quantities in the treated diabetic rats. Additionally, significant positive results were observed in the biochemical parameters, namely reduced plasma cholesterol, LDL cholesterol and triglycerides, plasma creatinine, and urea and uric acid levels, highlighting the seeds' use in traditional medicine. The results were sustained by histopathological observations that showed better tissue preservation following the flaxseed diet. Overall, the consumption of flaxseeds produced moderate reduction in glucose levels and hyperlipidemia, together with improvement in the impaired organs' function in diabetic rats. The daily administration of polyphenols and lignans compounds could impact therapeutic potential in diabetes management.
亚麻籽因其化学成分和公认的有益效果，在人类健康中发挥着重要作用。本研究调查了亚麻籽提取物中现有的木脂素和多酚对链脲佐菌素（STZ）诱导的糖尿病大鼠的抗糖尿病作用。给予亚麻籽后，治疗的糖尿病大鼠的体重、食物和水摄入量、糖化血红蛋白和血糖量均发生了有利变化。此外，在生化参数方面观察到显著的积极结果，即血浆胆固醇、低密度脂蛋白胆固醇和甘油三酯、血浆肌酐、尿素和尿酸水平降低，突出了这些种子在传统医学中的用途。组织病理学观察结果支持了这些结果，显示亚麻籽饮食后组织保存得更好。总体而言，食用亚麻籽可适度降低糖尿病大鼠的血糖水平和高脂血症，并改善受损器官的功能。每日给予多酚和木脂素化合物可能会影响糖尿病管理的治疗潜力。
