Kappler J W, Kushnir E, Marrack P
Howard Hughes Medical Institute, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
J Exp Med. 1989 May 1;169(5):1533-41. doi: 10.1084/jem.169.5.1533.
A set of new mouse strains were produced that carry the V beta a haplotype of the TCR-alpha/beta and any of a number of different H-2 haplotypes on backgrounds derived from related C57BL, C57L, and C57BR mice. Study of V beta 17a expression in these mice confirms the association between the presence of IE and the deletion of V beta 17a+ T cells. A second H-2 gene causing deletion of V beta 17a+ T cells was mapped in these mice to the K end of H-2k, and H-2 influences on the level of selection of CD4+ V beta 17a+ T cells were indicated.
培育出了一组新的小鼠品系,它们携带TCR-α/β的Vβa单倍型以及源自相关C57BL、C57L和C57BR小鼠背景的多种不同H-2单倍型中的任何一种。对这些小鼠中Vβ17a表达的研究证实了IE的存在与Vβ17a+ T细胞缺失之间的关联。在这些小鼠中,将导致Vβ17a+ T细胞缺失的第二个H-2基因定位到H-2k的K端,并表明了H-2对CD4+ Vβ17a+ T细胞选择水平的影响。