外周血嗜酸性粒细胞增多对下呼吸道感染哮喘患者炎症标志物的影响。
The effect of peripheral blood eosinophilia on inflammatory markers in asthmatic patients with lower respiratory tract infections.
作者信息
Cag Yakup, Pacal Yakup, Gunduz Mehmet, Isik Sakine, Kertmen Birgul Altinsoy, Toprak Necmettin, Ozaydin Sadik Erhan, Ozcetin Mustafa, Kut Arif
机构信息
1 Department of Paediatrics, University of Health Sciences Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey.
2 Department of Paediatric Pulmonology, Health Sciences Sureyyapasa Chest Disease and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey.
出版信息
J Int Med Res. 2019 Jun;47(6):2452-2460. doi: 10.1177/0300060519844859. Epub 2019 Apr 21.
BACKGROUND
To investigate the behaviour of the inflammatory marker neutrophil-to-lymphocyte ratio (NLR) in the presence of peripheral blood eosinophilia (PBE) in paediatric asthma patients with lower respiratory tract (LRT) infections.
METHODS
This retrospective study enrolled consecutive patients aged ≥5 years who were diagnosed with asthma and whose haemogram values were available. The patients were further subdivided based on the presence or absence of LRT infections and allergies. NLR and C-reactive protein (CRP) were evaluated in relation to the presence or absence of PBE (≥4% eosinophils).
RESULTS
A total of 991 patients were enrolled in the study. Patients with LRT infections had significantly higher leucocyte and neutrophil counts, a greater NLR and a higher level of CRP compared with patients without LRT infections. Overall, patients with PBE had significantly lower NLRs and CRP regardless of the presence or absence of an LRT infection. The PBE percentage showed moderate inverse correlations with NLR ( r = -0.34) and CRP ( r = -0.20).
CONCLUSION
The presence of PBE was significantly associated with lower NLR and CRP regardless of the presence or absence of an infectious condition.
背景
探讨患有下呼吸道（LRT）感染的小儿哮喘患者在存在外周血嗜酸性粒细胞增多（PBE）的情况下炎症标志物中性粒细胞与淋巴细胞比值（NLR）的表现。
方法
这项回顾性研究纳入了年龄≥5岁、被诊断为哮喘且有血常规值的连续患者。根据是否存在LRT感染和过敏将患者进一步细分。根据是否存在PBE（嗜酸性粒细胞≥4%）评估NLR和C反应蛋白（CRP）。
结果
共有991名患者纳入研究。与无LRT感染的患者相比，LRT感染患者的白细胞和中性粒细胞计数显著更高，NLR更高，CRP水平更高。总体而言，无论是否存在LRT感染，PBE患者的NLR和CRP均显著更低。PBE百分比与NLR（r = -0.34）和CRP（r = -0.20）呈中度负相关。
结论
无论是否存在感染情况，PBE的存在均与较低的NLR和CRP显著相关。
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