Bener A, Yousafzai M T
Department of Medical Statistics and Epidemiology, Hamad Medical Corporation; Department of Public Health, Weill Cornell Medical College, Qatar; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, The University of Manchester, Manchester, UK, .
Niger J Clin Pract. 2014 Sep-Oct;17(5):565-8. doi: 10.4103/1119-3077.141418.
There is strong evidence in the literature that there is an association between ABO blood group and certain diseases.
The aim of this study was to investigate any association between the ABO blood groups and diabetes mellitus (DM) in Qatar.
This was a sex-matched case-control study.
This study was carried out in the diabetic outpatient clinics and blood bank of the Hamad Medical Corporation (HMC) from April 2011 to December 2012.
The study included 1633 diabetic patients and 1650 nondiabetic apparently healthy controls. A total of 2148 adult patients above 18 years of age were selected consecutively from the diabetic clinics of the hospitals and 1633 patients gave consent to take part in this study, thus giving a response rate of 76%. A total of 2150 nondiabetic healthy adults above 18 years of age were recruited from the blood bank and 1650 individuals agreed to take part in this study, giving a response rate of 76.7%. Blood group of the recruited subjects was taken from the database of the Blood Bank, Central laboratory, HMC.
The data revealed that the blood group B was significantly more common in diabetic patients as compared with healthy population (25.7% vs. 20.4%; P < 0.001). Blood group O was significantly less common in diabetic patients compared with nondiabetics (38.5% vs. 45.4%; P < 0.001). Among diabetic men, the frequency of only blood group B was significantly higher, while on the contrary among diabetic women the frequency of both A and B (29.7% vs. 24.8%; P = 0.03 and 25.5% vs. 20%; P < 0.009, respectively) were significantly higher as compared with nondiabetic healthy population.
The findings in this study suggest that ABO antigens are associated with DM. DM is more common in individuals with blood group B.
文献中有强有力的证据表明ABO血型与某些疾病之间存在关联。
本研究的目的是调查卡塔尔人群中ABO血型与糖尿病（DM）之间的任何关联。
这是一项性别匹配的病例对照研究。
本研究于2011年4月至2012年12月在哈马德医疗公司（HMC）的糖尿病门诊和血库进行。
该研究纳入了1633例糖尿病患者和1650例非糖尿病的明显健康对照者。从医院的糖尿病诊所连续选取了2148例18岁以上的成年患者，其中1633例患者同意参与本研究，因此应答率为76%。从血库招募了2150例18岁以上的非糖尿病健康成年人，其中1650人同意参与本研究，应答率为76.7%。所招募受试者的血型取自HMC中央实验室血库的数据库。
数据显示，与健康人群相比，B型血在糖尿病患者中明显更为常见（25.7%对20.4%；P<0.001）。与非糖尿病患者相比，O型血在糖尿病患者中明显较少见（38.5%对45.4%；P<0.001）。在糖尿病男性中，仅B型血的频率显著更高，而相反，在糖尿病女性中，A和B型血的频率（分别为29.7%对24.8%；P = 0.03和25.5%对20%；P<0.009）与非糖尿病健康人群相比均显著更高。
本研究结果表明ABO抗原与糖尿病有关。糖尿病在B型血个体中更为常见。
