Sharjeel Simrah, Wasi Muhammad, Jafri Aliya, Raza Fatima A, Tariq Zara, Shamim Khizer, Abbas Kiran, Ahmed Moiz
Department of Medicine, Jinnah Sindh Medical University, Karachi, PAK.
Department of Biochemistry, Jinnah Sindh Medical University, Karachi, PAK.
Cureus. 2021 Nov 25;13(11):e19898. doi: 10.7759/cureus.19898. eCollection 2021 Nov.
Introduction Adult-onset type 2 diabetes mellitus (T2DM) is defined as a chronic hyperglycemic state, characterized by insulin resistance and declining islet B-cell function, eventually leading to islet B-cell function failure. The present study evaluated the association of T2DM with the type of blood group. Methodology A case-control study was conducted from April 2020 to September 2021 in Karachi, Pakistan. An electronic questionnaire was used to determine if there is an association between ABO blood groups and type 2 diabetes mellitus. Our study involved two groups with an equal number of participants. The patient group contained participants who had been diagnosed with type 2 diabetes mellitus, whereas the control group contained participants who had never been diagnosed with type 2 diabetes mellitus. Information was collected through a self-administered electronic questionnaire which was circulated through social media. Results The mean ± SD age was reported to be 25.98 ± 12 years. The study found a significant association between blood group B and type 2 diabetes mellitus (p=0.006), whereas a negative association was seen between the blood group O and type 2 diabetes mellitus (p=0.001). It should be noted, however, no significant association was found between the blood groups A and AB and type 2 diabetes mellitus (p>0.05). Conclusion The results of this study indicate that there is an association between type 2 diabetes mellitus and the ABO blood group system; a significant association was found between blood group B and risk of type 2 diabetes mellitus (T2DM). Nevertheless, we recommend regular screening for T2DM in individuals with a high-risk profile. Those at risk can adopt measures that are beneficial for them in the long run such as dietary control and physical exercise. Further studies using explorative techniques with a diversified population are recommended.
引言 成人发病型2型糖尿病（T2DM）被定义为一种慢性高血糖状态，其特征为胰岛素抵抗和胰岛β细胞功能衰退，最终导致胰岛β细胞功能衰竭。本研究评估了T2DM与血型类型之间的关联。
方法 2020年4月至2021年9月在巴基斯坦卡拉奇进行了一项病例对照研究。使用电子问卷来确定ABO血型与2型糖尿病之间是否存在关联。我们的研究涉及两组，参与者数量相等。患者组包含已被诊断患有2型糖尿病的参与者，而对照组包含从未被诊断患有2型糖尿病的参与者。信息通过自行填写的电子问卷收集，该问卷通过社交媒体分发。
结果 报告的平均±标准差年龄为25.98±12岁。研究发现B型血与2型糖尿病之间存在显著关联（p=0.006），而O型血与2型糖尿病之间存在负相关（p=0.001）。然而，应注意的是，A型血和AB型血与2型糖尿病之间未发现显著关联（p>0.05）。
结论 本研究结果表明2型糖尿病与ABO血型系统之间存在关联；发现B型血与2型糖尿病（T2DM）风险之间存在显著关联。尽管如此，我们建议对高危人群定期进行T2DM筛查。有风险的人可以采取从长远来看对他们有益的措施，如饮食控制和体育锻炼。建议使用探索性技术对多样化人群进行进一步研究。
