Legese Biruk, Abebe Molla, Fasil Alebachew
Infectious Disease Screening Division, Amhara National Regional State Health Bureau, Bahir Dar Blood Bank Laboratory, Bahir Dar, Ethiopia.
Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Int J Chronic Dis. 2020 Nov 5;2020:2535843. doi: 10.1155/2020/2535843. eCollection 2020.
ABO and Rh blood group antigens are thought to be among genetic determinants of type 2 diabetes mellitus. Identification of blood group phenotypes are more associated with type 2 diabetes mellitus. It will be helpful for individuals who are susceptible blood groups to take care of themselves by avoiding other predisposing factors and taking preventive measures.
Hospital-based comparative cross-sectional study was carried out from February to April 2019 at Felege Hiwot Comprehensive Referral Hospital. Sociodemographic and clinical data were collected with a semistructured pretested questionnaire. ABO and Rh Blood group were determined by slide and test tube methods. Biochemical parameters were determined with Mindray BS-200E fully automated clinical chemistry analyzer. Data were analyzed by IBM SPSS version 20 statistical software. Chi-square test and logistic regression analysis were employed for data analysis. A value of < 0.05 was considered statistically significant.
From a total of 424 participants included for this study, blood group O was found higher in frequency with 74 (34.9%) and 97 (45.75%) for cases and healthy controls, respectively. ABO blood groups showed significant association with T2DM, a chi-square value of 12.163 and value of 0.007. However, the Rh blood group was not associated with T2DM. Binary logistic regression analysis revealed that blood group B had a higher risk (OR: 2.12, 95% CI: 1.33-3.32) and blood group O had decreased risk (OR: 0.636, 95% CI: 0.43-0.94) of T2DM as compared to other blood groups.
ABO blood group antigens showed significant association with type 2 diabetes mellitus. Blood group B was associated with an increased risk and O blood group with decreased risk of type 2 diabetes mellitus.
ABO和Rh血型抗原被认为是2型糖尿病的遗传决定因素之一。血型表型的鉴定与2型糖尿病的关联更为密切。这将有助于血型易感性个体通过避免其他诱发因素和采取预防措施来照顾自己。
2019年2月至4月在费莱格·希沃特综合转诊医院开展了一项基于医院的比较横断面研究。通过一份经过预测试的半结构化问卷收集社会人口统计学和临床数据。采用玻片法和试管法测定ABO和Rh血型。使用迈瑞BS-200E全自动临床化学分析仪测定生化参数。数据采用IBM SPSS 20版统计软件进行分析。采用卡方检验和逻辑回归分析进行数据分析。P值<0.05被认为具有统计学意义。
在本研究纳入的424名参与者中，发现O型血的频率较高，病例组和健康对照组分别为74例（34.9%）和97例（45.75%）。ABO血型与2型糖尿病显示出显著关联，卡方值为12.163，P值为0.007。然而，Rh血型与2型糖尿病无关。二元逻辑回归分析显示，与其他血型相比，B型血患2型糖尿病的风险更高（OR：2.12，95%CI：1.33-3.32），O型血患2型糖尿病的风险降低（OR：0.636，95%CI：0.43-0.94）。
ABO血型抗原与2型糖尿病显示出显著关联。B型血与2型糖尿病风险增加相关，O型血与2型糖尿病风险降低相关。
