Unrelated donor HLA re-typing effort to verify prevalence of newer alleles: HLA-A*24:23, A*30:10, DRB1*08:11, DRB1*15:03, and DRB1*15:06.

The National Marrow Donor Program (NMDP) is committed to maintaining accurate human leukocyte antigen (HLA) data for each of the 11.5 million volunteer donors on the Be The Match Registry(®) . Qualitative data analysis identified five population specific alleles suspect of being incorrectly characterized. Alleles evaluated were HLA-A24:03 for the presence of A24:23 in Native Americans, A30:02 for the presence of A30:10 when B41 and DRB104:05 were in the haplotype, DRB108:02 for the presence of DRB108:11 in Native Americans, and DRB115:01 for the presence of DRB115:03 in African Americans or DRB1*15:06 in Asian donors. Discrepancy rate was 55%, 86%, 31%, 75%, and 13%, respectively. Utilizing the HLA typing date, race, and date an allele in question was described may provide a selection strategy leading to the consideration of additional unrelated donors for searching patients.