Gourraud Pierre-Antoine, Pappas Derek James, Baouz Amar, Balère Marie-Lorraine, Garnier Federico, Marry Evelyne
Dept. of Neurology, School of Medicine, University of California, San Francisco at San Francisco, CA, USA; Registre France Greffe de Moelle, Agence de la Biomédecine, Paris, France.
Children's Hospital Research Institute, Oakland, CA, USA.
Hum Immunol. 2015 May;76(5):381-4. doi: 10.1016/j.humimm.2015.01.028. Epub 2015 Jan 28.
We have estimated human leukocyte antigen (HLA) haplotype frequencies using the maximum likelihood mode, which accommodates typing ambiguities. The results of the frequency distribution of the 7015 haplotypes obtained are presented here. These include a total of 114 HLA-A, 185 HLA-B, and 76 HLA-DRB1 unique alleles at each locus. Across all populations, although the most common individual HLA alleles were HLA-A(∗)02:01 (29.0%), HLA-B(∗)07:02 (11.4%), and HLA-DRB1(∗)07:01 (15.9%), the most frequent haplotype was found to be HLA-A(∗)01:01∼B(∗)08:01∼DRB1(∗)03:01.
我们使用了最大似然模型估计人类白细胞抗原（HLA）单倍型频率，该模型可处理分型模糊性问题。本文展示了所获得的7015种单倍型的频率分布结果。这些结果包括每个基因座上总共114个HLA - A、185个HLA - B和76个HLA - DRB1独特等位基因。在所有人群中，尽管最常见的单个HLA等位基因是HLA - A(∗)02:01（29.0%）、HLA - B(∗)07:02（11.4%）和HLA - DRB1(∗)07:01（15.9%），但发现最常见的单倍型是HLA - A(∗)01:01∼B(∗)08:01∼DRB1(∗)03:01。
