Glowacki Andrew J, Gottardi Riccardo, Yoshizawa Sayuri, Cavalla Franco, Garlet Gustavo P, Sfeir Charles, Little Steven R
Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
Ann Biomed Eng. 2015 Mar;43(3):593-602. doi: 10.1007/s10439-014-1125-2. Epub 2014 Sep 23.
Disease and injury perturb the balance of processes associated with inflammation and tissue remodeling, resulting in positive feedback loops, exacerbation of disease and compromised tissue repair. Conversely, under homeostatic healthy conditions, these processes are tightly regulated through the expansion and/or recruitment of specific cell populations, promoting a balanced steady-state. Better understanding of these regulatory processes and recent advances in biomaterials and biotechnology have prompted strategies to utilize cells for the treatment and prevention of disease through regulation of inflammation and promotion of tissue repair. Herein, we describe how cells that regulate these processes can be increased in prevalence at a site of disease or injury. We review several relevant cell therapy approaches as well as new strategies for directing endogenous regulatory cells capable of promoting environmental homeostasis and even the establishment of a pro-regenerative micro-environment. Collectively, these examples may provide a blueprint for next-generation "medicine" that spurs the body's own cells to action and replaces conventional drugs.
疾病和损伤会扰乱与炎症和组织重塑相关的过程平衡，导致正反馈循环、疾病恶化以及组织修复受损。相反，在稳态健康条件下，这些过程通过特定细胞群体的扩增和/或募集受到严格调控，从而促进平衡的稳态。对这些调控过程的深入理解以及生物材料和生物技术的最新进展促使人们采取策略，通过调节炎症和促进组织修复，利用细胞来治疗和预防疾病。在此，我们描述了如何在疾病或损伤部位增加调控这些过程的细胞数量。我们回顾了几种相关的细胞治疗方法以及引导内源性调节细胞的新策略，这些细胞能够促进环境稳态甚至建立促再生微环境。总体而言，这些例子可能为下一代“药物”提供蓝图，促使人体自身细胞发挥作用并取代传统药物。
