Murakami M, Yoo J K, Teramura S, Inada M, Saita H, Matsuo K, Kusaka S, Kita T, Miyake T
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
Jpn J Pharmacol. 1989 May;50(1):72-4. doi: 10.1254/jjp.50.72.
We studied the effect of plasmin inhibitor on ethanol and ammonia-induced gastric mucosal lesions in rats using an ex vivo chamber. Tranexamic acid and aminocaproic acid significantly inhibited macroscopic gastric hemorrhagic necrosis and attenuated the decrease of gastric transmucosal potential difference induced by 50% ethanol and 1% ammonia. The protection of gastric mucosa afforded by tranexamic acid and aminocaproic acid was not affected by pretreatment with indomethacin (5 mg/kg). These results suggest that plasmin inhibitor plays an important role in the prevention of gastric deep necrosis following exposure of the stomach to a damaging agent.
我们使用离体腔室研究了纤溶酶抑制剂对乙醇和氨诱导的大鼠胃黏膜损伤的影响。氨甲环酸和氨基己酸显著抑制了肉眼可见的胃出血性坏死，并减轻了50%乙醇和1%氨诱导的胃跨黏膜电位差的降低。氨甲环酸和氨基己酸对胃黏膜的保护作用不受吲哚美辛（5毫克/千克）预处理的影响。这些结果表明，纤溶酶抑制剂在预防胃暴露于损伤剂后发生深度坏死中起重要作用。
