Li Man, Wan Li, Mei Wei, Tian Yuke
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Drug Des Devel Ther. 2014 Sep 9;8:1269-76. doi: 10.2147/DDDT.S57258. eCollection 2014.
We reviewed the Chinese and English literature for efficacy and tolerability data as well as pharmacological properties of ropivacaine in Chinese patients. Ropivacaine is a long-acting amide local anesthetic agent that elicits nerve block via reversible inhibition of sodium ion influx in nerve fibers. The available evidence in the literature on anesthesia practice indicates that ropivacaine produces equally surgical sensory block and postoperative and obstetrics analgesia with good maternal and fetal outcome to those of bupivacaine or levobupivacaine. It appears to be associated with comparable onset, quality, and duration of sensory block, but with a lower incidence or grade of motor block, compared to bupivacaine. The satisfaction of both patients and surgeons is high when ropivacaine is used. Thus, ropivacaine appears to be an important option for regional anesthesia and for the management of postoperative and labor pain, with its enhanced sensorimotor differentiation blockage at lower concentrations and enhanced safety at higher concentrations.
我们查阅了中英文文献，以获取关于罗哌卡因在中国患者中的疗效、耐受性数据以及药理特性。罗哌卡因是一种长效酰胺类局部麻醉剂，通过可逆性抑制神经纤维中的钠离子内流来引发神经阻滞。文献中关于麻醉实践的现有证据表明，与布比卡因或左旋布比卡因相比，罗哌卡因产生的外科手术感觉阻滞、术后镇痛和产科镇痛效果相同，对母婴结局良好。与布比卡因相比，它似乎具有相似的感觉阻滞起效时间、质量和持续时间，但运动阻滞的发生率或程度较低。使用罗哌卡因时，患者和外科医生的满意度都很高。因此，罗哌卡因似乎是区域麻醉以及术后和分娩疼痛管理的重要选择，因为它在较低浓度下增强了感觉运动分离阻滞，在较高浓度下增强了安全性。
