黑种草籽乙醇提取物对雄性大鼠生育潜能、血浆促性腺激素和睾酮的增强作用。
The enhancing effects of alcoholic extract of Nigella sativa seed on fertility potential, plasma gonadotropins and testosterone in male rats.
作者信息
Parandin Rahmatollah, Yousofvand Namdar, Ghorbani Rostam
机构信息
Department of Animal Physiology-Biology, Faculty of Sciences, Payame Noor University of Tehran, Tehran, Iran.
Department of Biology, Faculty of Sciences, Razi University of Kermanshah, Kermanshah, Iran.
出版信息
Iran J Reprod Med. 2012 Jul;10(4):355-62.
BACKGROUND
The task force on plants for fertility regulation in men continued with its program to identify novel prototypes in plants alleged to have fertility regulating properties. Nigella Sativa seeds are frequently used in folk medicine in the Middle East and some Asian countries for the promotion of good health and treatment of many ailments.
OBJECTIVE
To evaluated the role of alcoholic extract of Nigella sativa on fertility potential, Pituitary-testicular axis hormones and Testosterone in male rats.
MATERIALS AND METHODS
24 male rats were randomly divided into 3 groups; control, group A and group B, each group comprising of 8 rats. Animals in control group received 1 ml of normal saline and treatment groups (A and B) received (gavage) graded doses of 200 and 400 mg/kg body weight of alcoholic extract of Nigella sativa seeds on a daily basis for 60 days. At the end of treatment period, fertility parameters such as body and reproductive organs weight, sperm motility, viability and count, epididymal sperm reserve (ESR), daily sperm production (DSP), blood testosterone concentration, Gonadotropins levels and fertility index were measured.
RESULTS
There was a significant difference in testes and epididymidis weight, sperm count, ESR, DSP, blood testosterone concentration, LH and fertility index in both the lower dose group and the higher group as compared to the control group.
CONCLUSION
The results of this study showed that alcoholic extract of Nigella sativa seed especially in higher doses could increase fertility potential, LH and testosterone concentration in male rats.
背景
男性生育调节植物特别工作组继续其项目，以确定据称具有生育调节特性的新型植物原型。黑种草籽在中东和一些亚洲国家的民间医学中经常用于促进健康和治疗多种疾病。
目的
评估黑种草酒精提取物对雄性大鼠生育潜能、垂体-睾丸轴激素和睾酮的作用。
材料与方法
将24只雄性大鼠随机分为3组；对照组、A组和B组，每组8只大鼠。对照组动物接受1毫升生理盐水，治疗组（A组和B组）每天经口灌胃给予200和400毫克/千克体重的黑种草籽酒精提取物，持续60天。在治疗期结束时，测量生育参数，如身体和生殖器官重量、精子活力、存活率和计数、附睾精子储备（ESR）、每日精子产量（DSP）、血液睾酮浓度、促性腺激素水平和生育指数。
结果
与对照组相比，低剂量组和高剂量组的睾丸和附睾重量、精子计数、ESR、DSP、血液睾酮浓度、促黄体生成素（LH）和生育指数均存在显著差异。
结论
本研究结果表明，黑种草籽酒精提取物，尤其是高剂量时，可提高雄性大鼠的生育潜能、LH和睾酮浓度。
Zotero 插件