Armstrong Kathryn R, Cote Anita T, Devlin Angela M, Harris Kevin C
Division of Cardiology, BC Children's Hospital, Children's Heart Centre, 1F-4480 Oak Street, Vancouver, BC, V6H 3 V4, Canada.
Curr Treat Options Cardiovasc Med. 2014 Nov;16(11):339. doi: 10.1007/s11936-014-0339-9.
Childhood obesity is associated with progressive vascular dysfunction as manifest by arterial stiffness and elevated blood pressure with associated subsequent morbidity and mortality because of early cardiovascular events including myocardial infarction and stroke in adulthood. Consequently, the recent dramatic increases in childhood obesity around the world present a hitherto unforeseen public health concern. While coordinated primary prevention efforts remain an ongoing important focus of action, identification and treatment of modifiable cardiovascular risk factors in pediatric patients is necessary given the existing burden of disease and future health consequences. Lifestyle interventions remain a cornerstone of our therapeutic approach, however, medical therapy is needed in some cases and should not be underutilized based on patient age. Herein, we discuss the relationship between childhood obesity and hypertension with a key emphasis on the evolution of adaptive and maladaptive vascular changes in the genesis of overt cardiovascular disease.
儿童肥胖与进行性血管功能障碍相关，表现为动脉僵硬和血压升高，随后由于成年期早期心血管事件（包括心肌梗死和中风）而导致发病和死亡。因此，最近全球儿童肥胖率的急剧上升带来了前所未有的公共卫生问题。虽然协调一致的一级预防努力仍然是持续的重要行动重点，但鉴于现有的疾病负担和未来的健康后果，识别和治疗儿科患者中可改变的心血管危险因素是必要的。生活方式干预仍然是我们治疗方法的基石，然而，在某些情况下需要药物治疗，不应基于患者年龄而未充分利用。在此，我们讨论儿童肥胖与高血压之间的关系，重点强调适应性和适应性不良血管变化在明显心血管疾病发生过程中的演变。
