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使用非定制支架型人工血管对胸腹主动脉瘤进行完全腔内修复

Total endovascular repair of thoracoabdominal aortic aneurysms with non-customized stent grafts.

作者信息

Zhang Yongxue, Lu Qingsheng, Pei Yifei, Wu Mengtao, Zhang Suming, Hong Yi, Jing Zaiping

机构信息

Division of Vascular Surgery, Changhai Hospital, Shanghai, China; Military Institute of Vascular Disease, the First Affiliated Hospital of the Second Military Medical University, Shanghai, China.

Division of Vascular Surgery, Changhai Hospital, Shanghai, China.

出版信息

Ann Thorac Surg. 2014 Nov;98(5):1606-12. doi: 10.1016/j.athoracsur.2014.06.064. Epub 2014 Sep 22.

Abstract

BACKGROUND

Total endovascular repair of thoracoabdominal aortic aneurysms with customized branched or fenestrated endografts could be technically challenging outside large-volume centers. This study aims to describe a new endovascular strategy for use of both noncustomized stent grafts and flow-diverting stents in treating complicated thoracoabdominal aortic aneurysms.

METHODS

Patients diagnosed with thoracoabdominal aortic aneurysms and deemed unfit for open surgical repair were recruited. The aim of the procedure was to cover the renovisceral segment of the aorta with flow-diverting uncovered stents, while covering the remaining aneurysm with stent grafts. Aneurysm morphologic evolution and the patency of the visceral branches were assessed at follow-up.

RESULTS

Between February 2012 and August 2013, 6 selective patients (4 men, mean age 58 years) underwent the novel joint procedure. During mean follow-up of 14 months, aneurysm shrinkage (maximum diameter decrease >5 mm) was demonstrated in 4 patients and aneurysm stabilization (maximum diameter decrease <5 mm) was observed in 2 patients. No aneurysm expansion was observed in any participants. Mean aneurysm diameter decreased from 65.0±8.8 mm to 58.5±12.2 mm (p=0.054), with a significant increase in average sac thrombus deposition volume (sac thrombosis ratio increased from 23.3%±7.4% to 98.0%±3.3%, p<0.001). The majority of side branches (23 of 24) were successfully preserved.

CONCLUSIONS

Complete endovascular repair of thoracoabdominal aortic aneurysms with this novel joint procedure may be a feasible alternative in high surgical risk patients. Further validation of this technique is required to substantiate these results.

摘要

背景

在大型医疗中心以外,使用定制的分支型或开窗型血管内移植物对胸腹主动脉瘤进行全腔内修复在技术上可能具有挑战性。本研究旨在描述一种新的血管内治疗策略,即使用非定制的覆膜支架和血流导向支架治疗复杂的胸腹主动脉瘤。

方法

招募被诊断为胸腹主动脉瘤且不适合开放手术修复的患者。该手术的目的是用未覆膜的血流导向支架覆盖主动脉的肾动脉内脏段,同时用覆膜支架覆盖其余的动脉瘤。在随访中评估动脉瘤的形态演变和内脏分支的通畅情况。

结果

2012年2月至2013年8月期间,6例经过筛选的患者(4例男性,平均年龄58岁)接受了这种新型联合手术。在平均14个月的随访期间,4例患者出现动脉瘤缩小(最大直径减少>5mm),2例患者动脉瘤稳定(最大直径减少<5mm)。所有参与者均未观察到动脉瘤扩张。平均动脉瘤直径从65.0±8.8mm降至58.5±12.2mm(p=0.054),瘤腔内血栓沉积体积显著增加(瘤腔血栓形成率从23.3%±7.4%增至98.0%±3.3%,p<0.001)。大多数分支(24支中的23支)得以成功保留。

结论

对于手术风险高的患者,采用这种新型联合手术对胸腹主动脉瘤进行完全腔内修复可能是一种可行的替代方案。需要对该技术进行进一步验证以证实这些结果。

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