Lestringant G G, Berge T
Department of Dermatology, Al-Hada Military Hospital, Taif, Kingdom of Saudi Arabia.
Arch Dermatol. 1989 Jun;125(6):816-9.
Seven members from three generations of a Saudi family presented with porokeratosis punctata palmaris et plantaris (PPPP). In our series of patients, the disorder began in their early 20s, seemed to be transmitted as a dominant trait, and affected males only. The elementary lesion was a tiny keratotic spine, and the involvement was strictly limited to the volar aspects of the hands and to the soles of the feet. Histological studies showed a columnar parakeratosis that resembled the cornoid lamella of porokeratosis, but other clinical and histological traits tended to make PPPP an entity that was distinct from true porokeratosis. There have been only six reports in the literature on genuine PPPP before this series.
一个沙特家庭三代中的七名成员患有掌跖点状汗孔角化症（PPPP）。在我们的患者系列中，这种疾病始于他们20岁出头，似乎以显性性状遗传，且仅影响男性。基本损害是一个微小的角化棘，受累严格限于手掌和脚底的掌面。组织学研究显示柱状不全角化，类似于汗孔角化症的鸡眼样板，但其他临床和组织学特征倾向于使PPPP成为一种与真正的汗孔角化症不同的实体。在本系列之前，文献中仅有六篇关于真正PPPP的报道。
