Ebrahimi Abdolali, Larijani Leila, Moradi Afshin, Ebrahimi Mohamad Reza
Dept. of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Cancer Prev. 2013 Winter;6(1):36-43.
Hedgehog signalling pathway has not only a critical role in cell proliferation,differentiation and tissue polarity at embryonic period but also has a vital role in stem cell proliferation, tissue healing and carcinogenesis. Recent research has increased our understanding of this pathway and its relation to other signalling pathways. In addition, a large number of studies confirmed the alteration of Hh signalling pathway in various types of human malignancies including basal cell carcinomas, medulloblastomas, lung, gastrointestinal, ovarian, breast, prostate cancers and leukemia. More than 50 small biomolecules have been introduced which have inhibitory effects on Hh signalling pathway. Although, in many tumors some acceptable results have been showed in phase I clinical trial, closer studies are required to improve drug bioavailability, to decrease the side effects and to find the right small molecules for specific types of cancers, considering patients overall benefits as well.
刺猬信号通路不仅在胚胎期的细胞增殖、分化和组织极性中起关键作用，而且在干细胞增殖、组织愈合和癌症发生中也起着至关重要的作用。最近的研究增进了我们对该通路及其与其他信号通路关系的理解。此外，大量研究证实了Hh信号通路在各种人类恶性肿瘤中的改变，包括基底细胞癌、髓母细胞瘤、肺癌、胃肠道癌、卵巢癌、乳腺癌、前列腺癌和白血病。已经引入了50多种对Hh信号通路有抑制作用的小分子生物分子。尽管在许多肿瘤的I期临床试验中已经显示出一些可接受的结果，但仍需要更深入的研究来提高药物的生物利用度、减少副作用，并为特定类型的癌症找到合适的小分子，同时也要考虑患者的整体利益。
