Tavasoli Azita, Mehrazma Mitra, Hooman Nakisa, Afshar Khas Ladan
Dept. of Pediatric Neurology, Ali Asghar Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Oncopathology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Cancer Prev. 2013 Fall;6(4):227-30.
Paraneoplastic syndromes result from secretion of hormones, peptides or cytokines by tumor or immune cross-reactivity between malignant and normal tissues. These conditions are rare in children, but when the clinical presentation of patients with a tumor is unusual, these syndromes should be emphasized. Extrarenal tumors with renin-secretion are rare in children. They may be related to paraneoplastic syndromes. We report a 22-month-old infant with hepatoblastoma presented with severe hypertension and related neurologic symptoms due to high plasma renin activity. To the best of our knowledge, this is the second report of renin producing hepatoblastoma in the literature. However, due to lack of laboratory facilities such as immunohistochemical study or polyclonal antibody for human renin activity, we could not prove the secretion of renin just by tumor tissue cells, but this potentiality is very likely. Other intensive investigations did not show any other origin for rennin secretion or hypertension in this patient.
副肿瘤综合征是由肿瘤分泌激素、肽或细胞因子，或恶性组织与正常组织之间的免疫交叉反应引起的。这些情况在儿童中很少见，但当肿瘤患者的临床表现不寻常时，应重视这些综合征。儿童肾外肿瘤伴肾素分泌很少见。它们可能与副肿瘤综合征有关。我们报告一名22个月大的肝母细胞瘤婴儿，因血浆肾素活性高而出现严重高血压及相关神经症状。据我们所知，这是文献中关于产生肾素的肝母细胞瘤的第二篇报道。然而，由于缺乏免疫组织化学研究或人肾素活性多克隆抗体等实验室设施，我们无法仅通过肿瘤组织细胞证明肾素的分泌，但这种可能性非常大。其他深入检查未发现该患者肾素分泌或高血压的任何其他来源。
