晚餐摄入更多的每日热量会增加肥胖风险。一项基于人群的6年前瞻性队列研究。
Consuming more of daily caloric intake at dinner predisposes to obesity. A 6-year population-based prospective cohort study.
作者信息
Bo Simona, Musso Giovanni, Beccuti Guglielmo, Fadda Maurizio, Fedele Debora, Gambino Roberto, Gentile Luigi, Durazzo Marilena, Ghigo Ezio, Cassader Maurizio
机构信息
Department of Medical Sciences, University of Turin, Turin, Italy.
Emergency Department, Gradenigo Hospital, Turin, Italy.
出版信息
PLoS One. 2014 Sep 24;9(9):e108467. doi: 10.1371/journal.pone.0108467. eCollection 2014.
BACKGROUND/OBJECTIVES: It has been hypothesized that assuming most of the caloric intake later in the day leads to metabolic disadvantages, but few studies are available on this topic. Aim of our study was to prospectively examine whether eating more of the daily caloric intake at dinner leads to an increased risk of obesity, hyperglycemia, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD).
SUBJECTS/METHODS: 1245 non-obese, non-diabetic middle-aged adults from a population-based cohort underwent a 3-day food record questionnaire at enrollment. Anthropometric values, blood pressure, blood metabolic variables, and estimated liver fat were measured at baseline and at 6-year follow-up.
DESIGN
Prospective cohort study.
RESULTS
Subjects were divided according to tertiles of percent daily caloric intake at dinner. A significant increase in the incidence rate of obesity (from 4.7 to 11.4%), metabolic syndrome (from 11.1 to 16.1%), and estimated NAFLD (from 16.5 to 23.8%) was observed from the lower to higher tertile. In a multiple logistic regression model adjusted for multiple covariates, subjects in the highest tertile showed an increased risk of developing obesity (OR = 2.33; 95% CI 1.17-4.65; p = 0.02), metabolic syndrome (OR = 1.52; 95% CI 1.01-2.30; p = 0.04), and NAFLD (OR = 1.56; 95% CI 1.10-2.22; p = 0.01).
CONCLUSIONS
Consuming more of the daily energy intake at dinner is associated with an increased risk of obesity, metabolic syndrome, and NAFLD.
背景/目的：有假设认为，一天中大部分热量摄入较晚可能会导致代谢方面的不利影响，但关于该主题的研究较少。我们研究的目的是前瞻性地检验晚餐时摄入更多每日热量是否会增加肥胖、高血糖、代谢综合征和非酒精性脂肪性肝病（NAFLD）的风险。
受试者/方法：来自一个基于人群的队列中的1245名非肥胖、非糖尿病中年成年人在入组时进行了为期3天的饮食记录问卷调查。在基线和6年随访时测量人体测量值、血压、血液代谢变量和估计的肝脏脂肪。
设计
前瞻性队列研究。
结果
根据晚餐时每日热量摄入百分比的三分位数对受试者进行分组。从较低三分位数到较高三分位数，观察到肥胖发病率（从4.7%增至11.4%）、代谢综合征发病率（从11.1%增至16.1%）和估计的NAFLD发病率（从16.5%增至23.8%）显著增加。在针对多个协变量进行调整的多元逻辑回归模型中，最高三分位数的受试者发生肥胖（OR = 2.33；95% CI 1.17 - 4.65；p = 0.02）、代谢综合征（OR = 1.52；95% CI 1.01 - 2.30；p = 0.04）和NAFLD（OR = 1.56；95% CI 1.10 - 2.22；p = 0.01）的风险增加。
结论
晚餐时摄入更多每日能量摄入与肥胖、代谢综合征和NAFLD风险增加相关。
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