Diabetes Unit E. Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Holon, 58100, Israel.
Obesity (Silver Spring). 2013 Dec;21(12):2504-12. doi: 10.1002/oby.20460. Epub 2013 Jul 2.
Few studies examined the association between time-of-day of nutrient intake and the metabolic syndrome. Our goal was to compare a weight loss diet with high caloric intake during breakfast to an isocaloric diet with high caloric intake at dinner.
Overweight and obese women (BMI 32.4 ± 1.8 kg/m(2) ) with metabolic syndrome were randomized into two isocaloric (~1400 kcal) weight loss groups, a breakfast (BF) (700 kcal breakfast, 500 kcal lunch, 200 kcal dinner) or a dinner (D) group (200 kcal breakfast, 500 kcal lunch, 700 kcal dinner) for 12 weeks.
The BF group showed greater weight loss and waist circumference reduction. Although fasting glucose, insulin, and ghrelin were reduced in both groups, fasting glucose, insulin, and HOMA-IR decreased significantly to a greater extent in the BF group. Mean triglyceride levels decreased by 33.6% in the BF group, but increased by 14.6% in the D group. Oral glucose tolerance test led to a greater decrease of glucose and insulin in the BF group. In response to meal challenges, the overall daily glucose, insulin, ghrelin, and mean hunger scores were significantly lower, whereas mean satiety scores were significantly higher in the BF group.
High-calorie breakfast with reduced intake at dinner is beneficial and might be a useful alternative for the management of obesity and metabolic syndrome.
很少有研究探讨营养摄入的时间与代谢综合征之间的关系。我们的目标是比较早餐时高热量摄入的减肥饮食与晚餐时高热量摄入的等热量饮食。
超重和肥胖的患有代谢综合征的女性（BMI 32.4±1.8kg/m²）被随机分为两组等热量（约 1400kcal）减肥组，即早餐组（BF）（700kcal 早餐，500kcal 午餐，200kcal 晚餐）或晚餐组（D）（200kcal 早餐，500kcal 午餐，700kcal 晚餐），持续 12 周。
BF 组体重减轻和腰围减少更明显。虽然两组的空腹血糖、胰岛素和 ghrelin 均降低，但 BF 组的空腹血糖、胰岛素和 HOMA-IR 降低幅度更大。BF 组的平均甘油三酯水平降低了 33.6%，而 D 组则增加了 14.6%。口服葡萄糖耐量试验导致 BF 组的血糖和胰岛素显著降低。在餐食挑战中，BF 组的整体日间血糖、胰岛素、ghrelin 和平均饥饿评分显著降低，而平均饱腹感评分显著升高。
早餐时摄入高热量、晚餐时减少热量摄入对肥胖和代谢综合征的治疗有益，可能是一种有用的替代方法。
