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1
Phenotypic and functional alteration of CD4+ T cells after antigen stimulation. Resolution of two populations of memory T cells that both secrete interleukin 4.抗原刺激后CD4+ T细胞的表型和功能改变。两种均分泌白细胞介素4的记忆性T细胞群体的解析。
J Exp Med. 1989 Jun 1;169(6):2245-50. doi: 10.1084/jem.169.6.2245.
2
Murine CD4+ T cell subsets defined.已定义的小鼠CD4 + T细胞亚群。
J Exp Med. 1988 Nov 1;168(5):1825-38. doi: 10.1084/jem.168.5.1825.
3
Characterization of antigen-specific CD4+ effector T cells in vivo: immunization results in a transient population of MEL-14-, CD45RB- helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon gamma.体内抗原特异性CD4 +效应T细胞的特征：免疫接种导致一群短暂存在的MEL - 14 -、CD45RB -辅助细胞，这些细胞分泌白细胞介素2（IL - 2）、IL - 3、IL - 4和干扰素γ 。
J Exp Med. 1991 Sep 1;174(3):547-59. doi: 10.1084/jem.174.3.547.
4
Memory effectors: a potent, IL-4-secreting helper T cell population that develops in vivo after restimulation with antigen.记忆效应细胞：一种强效的、分泌白细胞介素-4的辅助性T细胞群体，在抗原再次刺激后于体内形成。
J Immunol. 1993 Apr 15;150(8 Pt 1):3119-30.
5
Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptor.来自脾脏的长期CD4+记忆T细胞缺乏淋巴结归巢受体MEL-14。
J Immunol. 1992 Jan 15;148(2):324-31.
6
In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate T-B cell interactions.体内CD40与gp39的相互作用对于胸腺依赖性体液免疫至关重要。I. CD40配体的体内表达、细胞因子及抗体产生描绘了同源T细胞与B细胞相互作用的位点。
J Exp Med. 1993 Nov 1;178(5):1555-65. doi: 10.1084/jem.178.5.1555.
7
Two distinct non-T helper type 2 interleukin-4+ cell subsets in mice as revealed by single-cell cytokine analysis.单细胞细胞因子分析揭示小鼠中两个不同的非2型辅助性T细胞白细胞介素-4⁺细胞亚群。
Eur J Immunol. 1994 Mar;24(3):549-57. doi: 10.1002/eji.1830240309.
8
Functional heterogeneity among human inducer T cell clones.人类诱导性T细胞克隆之间的功能异质性。
J Immunol. 1988 Jun 15;140(12):4211-6.
9
Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.活化的人CD4 +和CD8 + T细胞克隆同时产生白细胞介素-2、白细胞介素-4和干扰素-γ 。
J Immunol. 1988 Aug 1;141(3):849-55.
10
IL-4 synthesis by in vivo primed keyhole limpet hemocyanin-specific CD4+ T cells. I. Influence of antigen concentration and antigen-presenting cell type.体内致敏的钥孔戚血蓝蛋白特异性CD4 + T细胞合成白细胞介素-4。I. 抗原浓度和抗原呈递细胞类型的影响。
J Immunol. 1992 Dec 1;149(11):3468-76.

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1
3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance.3G11 在 CD4+T 细胞介导的自身免疫和免疫耐受中的表达。
Int Immunopharmacol. 2011 May;11(5):593-6. doi: 10.1016/j.intimp.2010.11.005. Epub 2010 Nov 24.
2
Targeting ganglioside epitope 3G11 on the surface of CD4+ T cells suppresses EAE by altering the Treg/Th17 cell balance.针对 CD4+T 细胞表面的神经节苷脂表位 3G11，通过改变调节性 T 细胞/辅助性 T17 细胞平衡来抑制 EAE。
Int Immunol. 2010 Oct;22(10):817-26. doi: 10.1093/intimm/dxq432. Epub 2010 Aug 2.
3
Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation.外周CD4(+)淋巴细胞分化过程中TCR和共刺激信号对Kv通道表达及功能的调节
J Exp Med. 2002 Oct 7;196(7):897-909. doi: 10.1084/jem.20020381.
4
Induction by a lactic acid bacterium of a population of CD4(+) T cells with low proliferative capacity that produce transforming growth factor beta and interleukin-10.一种乳酸菌诱导产生一群增殖能力低、能产生转化生长因子β和白细胞介素-10的CD4(+) T细胞。
Clin Diagn Lab Immunol. 2001 Jul;8(4):695-701. doi: 10.1128/CDLI.8.4.695-701.2001.
5
Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts of genetically different inbred mouse strains.来自基因不同的近交系小鼠脾脏T淋巴母细胞的中性糖鞘脂和神经节苷脂。
Glycoconj J. 1997 Feb;14(2):241-8. doi: 10.1023/a:1018597906798.
6
Antigen-independent changes in naive CD4 T cells with aging.随着年龄增长，初始CD4 T细胞发生的抗原非依赖性变化。
J Exp Med. 1996 Nov 1;184(5):1891-900. doi: 10.1084/jem.184.5.1891.
7
Allergen-dependent induction of interleukin-4 synthesis in vivo.变应原依赖的体内白细胞介素-4合成诱导
Immunology. 1993 Jan;78(1):74-9.
8
Characterization and augmentation of CD4+ cytotoxic T cell lines against melanoma.针对黑色素瘤的CD4+细胞毒性T细胞系的特性鉴定与增强
Cancer Immunol Immunother. 1994 Sep;39(3):172-8. doi: 10.1007/BF01533383.
9
Single exposure of mice to Borrelia burgdorferi elicits immunoglobulin G antibodies characteristic of secondary immune response without production of interleukin-4 by immune T cells.小鼠单次暴露于伯氏疏螺旋体后会引发具有二次免疫反应特征的免疫球蛋白G抗体，且免疫T细胞不会产生白细胞介素-4。
Infect Immun. 1995 Jul;63(7):2596-603. doi: 10.1128/iai.63.7.2596-2603.1995.
10
IL-4 synthesis by in vivo-primed memory CD4+ T cells: II. Presence of IL-4 is not required for IL-4 synthesis in primed CD4+ T cells.
J Clin Immunol. 1995 Mar;15(2):105-15. doi: 10.1007/BF01541738.

本文引用的文献

1
Isolation of high-affinity memory B cells: phycoerythrin as a probe for antigen-binding cells.高亲和力记忆B细胞的分离：藻红蛋白作为抗原结合细胞的探针。
Proc Natl Acad Sci U S A. 1987 Mar;84(5):1379-83. doi: 10.1073/pnas.84.5.1379.
2
Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations.初始及抗原刺激淋巴细胞群体中分泌白细胞介素-2和白细胞介素-4的T细胞频率。
J Immunol. 1988 May 15;140(10):3352-7.
3
Human naive and memory T cells: reinterpretation of helper-inducer and suppressor-inducer subsets.人类天然和记忆性T细胞：辅助诱导和抑制诱导亚群的重新诠释
Immunol Today. 1988 Jul-Aug;9(7-8):195-9. doi: 10.1016/0167-5699(88)91212-1.
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Lymphokine production by murine T cells in the mixed leukocyte reaction.混合淋巴细胞反应中鼠T细胞的淋巴因子产生
J Exp Med. 1988 Aug 1;168(2):795-800. doi: 10.1084/jem.168.2.795.
5
Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.两种小鼠辅助性T细胞克隆。III. 通过RNA杂交、功能单特异性生物测定法和单克隆抗体揭示的Th1和Th2克隆在淋巴因子合成方面的进一步差异。
J Exp Med. 1987 Nov 1;166(5):1229-44. doi: 10.1084/jem.166.5.1229.
6
Murine CD4+ T cell subsets defined.已定义的小鼠CD4 + T细胞亚群。
J Exp Med. 1988 Nov 1;168(5):1825-38. doi: 10.1084/jem.168.5.1825.
7
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.两种小鼠辅助性T细胞克隆。I. 根据淋巴因子活性和分泌蛋白谱进行的定义。
J Immunol. 1986 Apr 1;136(7):2348-57.
8
Generation of T memory cells in one-way mixed lymphocyte culture. III. Homing and lifetime of "secondary" lymphocytes.单向混合淋巴细胞培养中T记忆细胞的产生。III. “二级”淋巴细胞的归巢与寿命
Cell Immunol. 1975 May;17(1):165-80. doi: 10.1016/s0008-8749(75)80017-7.

抗原刺激后CD4+ T细胞的表型和功能改变。两种均分泌白细胞介素4的记忆性T细胞群体的解析。

Phenotypic and functional alteration of CD4+ T cells after antigen stimulation. Resolution of two populations of memory T cells that both secrete interleukin 4.

作者信息

Hayakawa K, Hardy R R

机构信息

Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.

出版信息

J Exp Med. 1989 Jun 1;169(6):2245-50. doi: 10.1084/jem.169.6.2245.

DOI:10.1084/jem.169.6.2245
PMID:2525174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189327/
Abstract

Phenotypic and functional alteration of murine CD4+ T cells after antigenic stimulation was studied using two anti-T cell mAbs recently described that define four distinct T cell subsets. Activation of T cells resulted in the permanent loss of 3G11 expression. However, two phenotypically distinct memory T cell populations were established depending on the system used; whereas those for anti-KLH antibody response were enriched in the fraction expression 6C10 (Fr. III), memory T cells for the allogeneic MLR lacked such expression (Fr. IV). Furthermore, successive stimulation with antigen in vitro resulted in secretion of IL-4 without detectable IL-2. This alteration of phenotype and interleukin secretion was also demonstrable when starting with 3G11+6C10- cells (Fr. I), the fraction that secretes IL-2 exclusively upon activation.

摘要

利用最近描述的两种抗T细胞单克隆抗体（mAbs）定义四个不同的T细胞亚群，研究了抗原刺激后小鼠CD4 + T细胞的表型和功能改变。T细胞的激活导致3G11表达的永久性丧失。然而，根据所使用的系统建立了两个表型不同的记忆T细胞群体；抗钥孔血蓝蛋白（KLH）抗体反应的记忆T细胞在表达6C10的部分（III组）中富集，而同种异体混合淋巴细胞反应（MLR）的记忆T细胞缺乏这种表达（IV组）。此外，体外连续用抗原刺激导致分泌白细胞介素-4（IL-4）而未检测到白细胞介素-2（IL-2）。当从3G11 + 6C10-细胞（I组）开始时，这种表型和白细胞介素分泌的改变也得到证实，该部分细胞仅在激活时分泌IL-2。