具有两性离子主链结构的DNA寡核苷酸的合成与性质
Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure.
作者信息
Schmidtgall Boris, Spork Anatol P, Wachowius Falk, Höbartner Claudia, Ducho Christian
机构信息
University of Paderborn, Department of Chemistry, Warburger Str. 100, 33 098 Paderborn, Germany.
出版信息
Chem Commun (Camb). 2014 Nov 18;50(89):13742-5. doi: 10.1039/c4cc06371f.
PMID:25251903
Abstract
The nucleosyl amino acid (NAA)-modification of oligonucleotides is introduced, which enables the preparation of oligonucleotides with zwitterionic backbone structures. It is demonstrated that partially zwitterionic NAA-modified DNA oligonucleotides are capable of duplex formation with native polyanionic counterstrands and show retained sensitivity towards base-pairing mismatches.
摘要
引入了寡核苷酸的核苷酰氨基酸（NAA）修饰，这使得能够制备具有两性离子主链结构的寡核苷酸。结果表明，部分两性离子的NAA修饰的DNA寡核苷酸能够与天然的聚阴离子互补链形成双链，并对碱基配对错配保持敏感性。
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