Teo Ruijie D, Gray Harry B, Lim Punnajit, Termini John, Domeshek Elena, Gross Zeev
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Chem Commun (Camb). 2014 Nov 18;50(89):13789-92. doi: 10.1039/c4cc06577h.
We have synthesized and characterized a water-soluble gold(III) corrole (1-Au) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au, which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of 1-Au may be related to this lower HSA affinity.
我们合成并表征了一种对顺铂耐药癌细胞具有高毒性的水溶性金（III）卟吩（1-Au）。相对于其1-Ga类似物，轴向配体与1-Au的结合较弱，这可能是其对人血清白蛋白（HSA）亲和力较低的原因。我们认为1-Au的细胞毒性可能与此较低的HSA亲和力有关。
