Hoter Abdullah, Rizk Sandra, Naim Hassan Y
Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hanover, Germany.
Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Front Mol Biosci. 2020 Apr 15;7:60. doi: 10.3389/fmolb.2020.00060. eCollection 2020.
Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Unlike other HSPs which clearly increase in some cancers, data about HSP60 levels in HCC are controversial and difficult to interpret. In the current review, we summarize and simplify the current knowledge about the role of HSP60 in HCC. In addition, we highlight the possibility of its targeting, using chemical compounds and/or genetic tools for treatment of HCC.
热休克蛋白60（HSP60）是一种线粒体伴侣蛋白，参与生理和病理过程。例如，它有助于蛋白质折叠和稳定性、线粒体蛋白的转运以及细胞凋亡。HSP60表达水平的变化与包括肝细胞癌（HCC）在内的各种疾病和癌症相关。与其他在某些癌症中明显增加的热休克蛋白不同，关于HCC中HSP60水平的数据存在争议且难以解释。在本综述中，我们总结并简化了目前关于HSP60在HCC中作用的知识。此外，我们强调了使用化学化合物和/或基因工具靶向治疗HCC的可能性。
