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维生素D:最新进展及其对运动员的影响

Vitamin D: recent advances and implications for athletes.

作者信息

Todd Joshua J, Pourshahidi L Kirsty, McSorley Emeir M, Madigan Sharon M, Magee Pamela J

机构信息

Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, UK.

出版信息

Sports Med. 2015 Feb;45(2):213-29. doi: 10.1007/s40279-014-0266-7.

DOI:10.1007/s40279-014-0266-7
PMID:25252613
Abstract

Athletes may be predisposed to low vitamin D concentrations, with studies reporting a high prevalence of athletes with a vitamin D concentration below 50 nmol/L across a range of sports and geographical locations, particularly over the winter months. It is well documented that vitamin D is important for osseous health by enhancing calcium absorption at the small intestine; however, emerging research suggests that vitamin D may also benefit a plethora of extra-skeletal target tissues and systems. There is strong evidence that vitamin D is capable of regulating both innate and adaptive immune processes via binding of active vitamin D to its complementary receptor. Supplementation with vitamin D may also enhance skeletal muscle function through morphological adaptations and enhanced calcium availability during cross-bridge cycling; however, an exact mechanism of action is yet to be elucidated. Such findings have prompted research into the importance of maintaining vitamin D concentrations over wintertime and the possible physiological and immunological benefits of vitamin D supplementation in athletes. The following review critically evaluates existing literature and presents novel perspectives on how vitamin D may enhance athletic performance.

摘要

运动员可能易患维生素D浓度低的情况,研究报告称,在一系列运动项目和不同地理位置中,尤其是在冬季,维生素D浓度低于50 nmol/L的运动员比例很高。有充分的文献记载,维生素D通过增强小肠对钙的吸收对骨骼健康很重要;然而,新出现的研究表明,维生素D可能也有益于大量骨骼外的靶组织和系统。有强有力的证据表明,活性维生素D与其互补受体结合后,维生素D能够调节先天性和适应性免疫过程。补充维生素D还可能通过形态学适应和在横桥循环过程中提高钙的可用性来增强骨骼肌功能;然而,确切的作用机制尚待阐明。这些发现促使人们研究在冬季维持维生素D浓度的重要性以及补充维生素D对运动员可能产生的生理和免疫益处。以下综述批判性地评估了现有文献,并就维生素D如何提高运动表现提出了新的观点。

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本文引用的文献

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Influence of vitamin d metabolites on plasma cytokine concentrations in endurance sport athletes and on multiantigen stimulated cytokine production by whole blood and peripheral blood mononuclear cell cultures.维生素D代谢产物对耐力运动运动员血浆细胞因子浓度以及对全血和外周血单个核细胞培养物中多抗原刺激的细胞因子产生的影响。
ISRN Nutr. 2014 Jan 1;2014:820524. doi: 10.1155/2014/820524. eCollection 2014.
2
The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers.维生素D受体(VDR)在雄性小鼠的骨骼肌中表达,并调节肌纤维对25-羟基维生素D(25OHD)的摄取。
Endocrinology. 2014 Sep;155(9):3227-37. doi: 10.1210/en.2014-1016. Epub 2014 Jun 20.
3
Annual Vitamin D Status of World-Class British Swimmers Following a Standardised Supplementation Protocol for Three Years.
遵循标准化补充方案三年后世界级英国游泳运动员的年度维生素D状况
Nutrients. 2025 Apr 5;17(7):1270. doi: 10.3390/nu17071270.
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Mechanism of Action and Beneficial Effects of Probiotics in Amateur and Professional Athletes.益生菌对业余和职业运动员的作用机制及有益效果
Food Sci Nutr. 2024 Dec 12;13(1):e4658. doi: 10.1002/fsn3.4658. eCollection 2025 Jan.
5
Association of Vitamin D Deficiency With Distal Biceps Injury: A Retrospective Analysis of 336,320 Patients.维生素D缺乏与肱二头肌远端损伤的关联:对336,320例患者的回顾性分析
Sports Health. 2024 Aug 27:19417381241273453. doi: 10.1177/19417381241273453.
6
Resveratrol and Vitamin D: Eclectic Molecules Promoting Mitochondrial Health in Sarcopenia.白藜芦醇和维生素 D:促进骨骼肌减少症中线粒体健康的折衷分子。
Int J Mol Sci. 2024 Jul 9;25(14):7503. doi: 10.3390/ijms25147503.
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A real-life snapshot: Evaluating exposures to low energy availability in male athletes from various sports.现实生活中的快照:评估来自不同运动项目的男性运动员的低能量状态暴露情况。
Physiol Rep. 2024 Jun;12(12):e16112. doi: 10.14814/phy2.16112.
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Patterns of energy availability and carbohydrate intake differentiate between adaptable and problematic low energy availability in female athletes.能量可利用模式和碳水化合物摄入量可区分女性运动员适应性低能量可利用状态和问题性低能量可利用状态。
Front Sports Act Living. 2024 May 9;6:1390558. doi: 10.3389/fspor.2024.1390558. eCollection 2024.
9
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Vitamin D status modulates innate immune responses and metabolomic profiles following acute prolonged cycling.维生素 D 状态可调节急性长时间骑行后的固有免疫反应和代谢组学特征。
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Vitamin D status and ill health: a systematic review.
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Lancet Diabetes Endocrinol. 2014 Jan;2(1):76-89. doi: 10.1016/S2213-8587(13)70165-7. Epub 2013 Dec 6.
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Severely vitamin D-deficient athletes present smaller hearts than sufficient athletes.严重维生素D缺乏的运动员的心脏比维生素D充足的运动员的心脏小。
Eur J Prev Cardiol. 2015 Apr;22(4):535-42. doi: 10.1177/2047487313518473. Epub 2014 Jan 7.
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Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans.在人类进行剧烈运动后,维生素D充足与抗炎细胞因子增加相关。
Cytokine. 2014 Feb;65(2):134-7. doi: 10.1016/j.cyto.2013.12.004. Epub 2013 Dec 31.
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Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells.维生素 D 信号调节 C2C12 骨骼肌细胞的增殖、分化和肌管大小。
Endocrinology. 2014 Feb;155(2):347-57. doi: 10.1210/en.2013-1205. Epub 2013 Nov 26.
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Effects of vitamin D in skeletal muscle: falls, strength, athletic performance and insulin sensitivity.维生素D对骨骼肌的影响:跌倒、力量、运动表现及胰岛素敏感性
Clin Endocrinol (Oxf). 2014 Feb;80(2):169-81. doi: 10.1111/cen.12368.
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An evaluation of the levels of vitamin d and bone turnover markers after the summer and winter periods in polish professional soccer players.波兰职业足球运动员在夏季和冬季后维生素 D 水平和骨转换标志物的评估。
J Hum Kinet. 2013 Oct 8;38:135-40. doi: 10.2478/hukin-2013-0053. eCollection 2013.
9
Vitamin D status and biomarkers of inflammation in runners.跑步者的维生素D状况与炎症生物标志物
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10
Sports health benefits of vitamin d.维生素D对运动健康的益处。
Sports Health. 2012 Nov;4(6):496-501. doi: 10.1177/1941738112461621.