Rutters Femke, Lemmens Sofie G, Adam Tanja C, Bremmer Marijke A, Elders Petra J, Nijpels Giel, Dekker Jacqueline M
Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, the Netherlands EMGO+ Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands
Department of Human Biology, Maastricht University, Maastricht, the Netherlands.
J Biol Rhythms. 2014 Oct;29(5):377-83. doi: 10.1177/0748730414550199. Epub 2014 Sep 24.
Social jetlag represents the discrepancy between circadian and social clocks, which is measured as the difference in hours in midpoint of sleep between work days and free days. Previous studies have shown social jetlag to be associated with body mass index (BMI), glycated hemoglobin levels, heart rate, depressive symptoms, smoking, mental distress and alcohol use. The objective of our current study was to investigate, in a group of 145 apparently healthy participants (67 men and 78 women, aged 18-55 years, BMI 18-35 kg/m(2)), the prevalence of social jetlag and its association with adverse endocrine, behavioral and cardiovascular risk profiles as measured in vivo. participants with ≥2 h social jetlag had higher 5-h cortisol levels, slept less during the week, were more often physically inactive and had an increased resting heart rate, compared with participants who had ≤1 h social jetlag. We therefore concluded that social jetlag is associated with an adverse endocrine, behavioral and cardiovascular risk profile in apparently healthy participants. These adverse profiles put healthy participants at risk for development of metabolic diseases and mental disorders, including diabetes and depression, in the near future.
社会时差反映了昼夜节律时钟与社会时钟之间的差异，其衡量方式为工作日和休息日睡眠中点时间的小时数差值。以往研究表明，社会时差与体重指数（BMI）、糖化血红蛋白水平、心率、抑郁症状、吸烟、精神困扰及饮酒有关。我们当前研究的目的是，在一组145名表面健康的参与者（67名男性和78名女性，年龄在18至55岁之间，BMI为18至35 kg/m²）中，调查社会时差的患病率及其与体内测量的不良内分泌、行为和心血管风险状况的关联。与社会时差≤1小时的参与者相比，社会时差≥2小时的参与者5小时皮质醇水平更高，一周内睡眠时间更少，身体活动更少的情况更常见，静息心率也更高。因此，我们得出结论，在表面健康的参与者中，社会时差与不良内分泌、行为和心血管风险状况有关。这些不良状况使健康参与者在不久的将来面临患代谢性疾病和精神障碍（包括糖尿病和抑郁症）的风险。
