Martínez-Albert Estefanía, Bless Josef J, Besedovsky Luciana
Institute of Medical Psychology, LMU Munich, Munich 80336, Germany.
Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Tübingen 72076, Germany.
Philos Trans R Soc Lond B Biol Sci. 2025 Jan 23;380(1918):20230472. doi: 10.1098/rstb.2023.0472.
Sleep deficiency is associated with infectious disease risk. However, little is known about the individual roles of different aspects of sleep, including sleep duration, sleep quality, sleep timing (assessed by chronotype) and sleep regularity (in the form of social jet lag) in this context. Here, we examined associations of the probability of reporting a cold or other infections with self-reported sleep duration, sleep quality and chronotype in a sample of 642 adults, and with social jet lag in a subsample of 274 adults. We found that short (≤ 6 h) and long sleepers (≥ 9 h) were more likely to report a cold in the past 30 days than average sleepers (7-8 h). Also, individuals with a definite evening chronotype were more likely to report a cold in the past 30 days than those with an intermediate chronotype, even when controlling for sleep duration. Finally, social jet lag was dose-dependently associated with the risk of reporting a cold in the past 12 months, independently of sleep duration, sleep quality and chronotype. No associations were found with sleep quality or with infections other than colds. The findings show that different aspects of sleep are independently associated with incidence of reported colds.This article is part of the Theo Murphy meeting issue 'Circadian rhythms in infection and immunity'.
睡眠不足与感染性疾病风险相关。然而，在此背景下，对于睡眠不同方面的个体作用，包括睡眠时间、睡眠质量、睡眠时间（通过昼夜节律类型评估）和睡眠规律性（以社会时差的形式），我们知之甚少。在此，我们在一个642名成年人的样本中，研究了报告感冒或其他感染的概率与自我报告的睡眠时间、睡眠质量和昼夜节律类型之间的关联，并在一个274名成年人的子样本中研究了其与社会时差的关联。我们发现，睡眠时间短（≤6小时）和长（≥9小时）的人在过去30天内比平均睡眠时间（7 - 8小时）的人更有可能报告感冒。此外，即使在控制睡眠时间后，具有明确夜型昼夜节律的个体在过去30天内比具有中间型昼夜节律的个体更有可能报告感冒。最后，社会时差与过去12个月内报告感冒的风险呈剂量依赖性关联，独立于睡眠时间、睡眠质量和昼夜节律类型。未发现与睡眠质量或除感冒以外的其他感染存在关联。研究结果表明，睡眠的不同方面与报告感冒的发生率独立相关。本文是西奥·墨菲会议议题“感染与免疫中的昼夜节律”的一部分。
