Cho Kyung Pyo, Lee Jae Sung, Seong Ji Seok, Woo Yong Moon, Cho Young Jun, Jeong Beom Jin, Sohn Jee Hoon, Kim Su-Jung
Department of Internal Medicine, Seoul Red Cross Hospital, Seoul, Korea.
Division of Public Health Medical Service, Seoul National University Hospital, Seoul, Korea.
Korean J Gastroenterol. 2014 Sep 25;64(3):158-63. doi: 10.4166/kjg.2014.64.3.158.
Wernicke's encephalopathy (WE) caused by thiamine deficiency is an acute neurological disorder. Clinically, the classic triad of WE consists of ophthalmoplegia, ataxia, and mental status changes. Thiamine deficiency is known to occur commonly in chronic alcoholic patients. Sometimes, it can occur in patients after gastrointestinal surgery and in those with malabsorption. In addition, patients undergoing renal dialysis, suffering from hyperemesis gravidarum, receiving total parenteral nutrition (TPN), and being treated with chemotherapeutic agents are also prone to develop thiamine deficiency. Herein, we report two cases of WE that developed following simultaneous 5-fluorouracil (5-FU) chemotherapy and TPN in colon cancer patients which was successfully treated with thiamine administration.
硫胺素缺乏所致的韦尼克脑病（WE）是一种急性神经障碍。临床上，WE的典型三联征包括眼肌麻痹、共济失调和精神状态改变。硫胺素缺乏常见于慢性酒精中毒患者。有时，也可发生于胃肠道手术后患者及吸收不良患者。此外，接受肾透析、患有妊娠剧吐、接受全胃肠外营养（TPN）以及接受化疗药物治疗的患者也容易发生硫胺素缺乏。在此，我们报告两例结肠癌患者在同时接受5-氟尿嘧啶（5-FU）化疗和TPN后发生的WE，经给予硫胺素治疗成功治愈。
