Gupta Anirban Sen
Nanomedicine (Lond). 2014 Jul;9(10):1517-29. doi: 10.2217/nnm.14.94.
The lethality of solid tumors is in large part dependent on their ability to metastasize through hematologic and lymphatic transport pathways. The dissemination of cancer cells from the primary tumor to undergo transport, their ability to survive in transit and then to subsequently form metastatic colonies, is facilitated by a complex concert of signaling pathways and cell-cell and cell-matrix interactions. Elucidating these mechanistic components is highly valuable to guide the development of technologies for efficiently detecting and treating metastasis. To this end, in recent years nanotechnology approaches have provided several unique detection, characterization and treatment strategies. The current article will review these approaches to discuss their promise and challenges, specifically in metastatic cancer, above and beyond the usual nanomedicine applications in cancer therapy.
实体瘤的致死性在很大程度上取决于其通过血液和淋巴转运途径发生转移的能力。癌细胞从原发肿瘤扩散并进行转运，它们在转运过程中存活并随后形成转移瘤的能力，是由信号通路以及细胞间和细胞与基质相互作用的复杂协同作用所促成的。阐明这些机制成分对于指导高效检测和治疗转移的技术发展具有极高的价值。为此，近年来纳米技术方法提供了几种独特的检测、表征和治疗策略。本文将综述这些方法，讨论它们的前景和挑战，特别是在转移性癌症方面，超越了癌症治疗中常见的纳米医学应用。
