Division of Surgical Oncology, Department of Surgery, University of Florida, Gainesville, Florida 32610, USA.
Nanomedicine. 2012 Sep;8 Suppl 1:S21-30. doi: 10.1016/j.nano.2012.05.011. Epub 2012 May 26.
Breast cancer represents a major ongoing public health problem as the most common non-cutaneous malignancy among U.S. women. While significant progress has been made in improving loco-regional treatments for breast cancer, relatively little progress has been made in diagnosing and treating patients with metastatic breast cancer. At present there are limited curative options for patients with breast cancer metastatic beyond regional nodes. Emerging nanotechnologies promise new approaches to early detection and treatment of metastatic breast cancer. Fulfilling the promise of nanotechnologies for patients with metastatic breast cancer will require delivery of nanomaterials to sites of metastatic disease. Future translational approaches will rely on an ever increasing understanding of the biology of breast cancer subtypes and their metastases. These important concepts will be highlighted and elucidated in this manuscript.
乳腺癌是美国女性中最常见的非皮肤恶性肿瘤，是一个持续存在的重大公共卫生问题。虽然在改善乳腺癌的局部区域治疗方面取得了重大进展，但在诊断和治疗转移性乳腺癌患者方面相对进展较小。目前，对于转移性乳腺癌患者，治愈的选择有限。新兴的纳米技术有望为转移性乳腺癌的早期检测和治疗提供新方法。为转移性乳腺癌患者实现纳米技术的承诺，需要将纳米材料递送到转移疾病部位。未来的转化方法将依赖于对乳腺癌亚型及其转移的生物学的不断深入了解。这些重要概念将在本手稿中重点阐述和阐明。
