纳米颗粒在癌症免疫治疗中的诊疗应用
Theranostics Applications of Nanoparticles in Cancer Immunotherapy.
作者信息
Liu Yihai, Wang Xixi, Hussain Mubashir, Lv Mu, Dong Xiaohan, Wang Tianying, Xu Xueqin, Liu Bin
机构信息
Department of Biomedical Engineering, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
出版信息
Med Sci (Basel). 2018 Nov 9;6(4):100. doi: 10.3390/medsci6040100.
With the advancement in the mechanism of immune surveillance and immune evasion in cancer cells, cancer immunotherapy shows promising results for treating cancer with established efficacy and less toxicity. As a result of the off-target effect, the approach for delivering vaccines, adjuvants, or antibodies directly to tumor sites is gaining widespread attention. An effective alternative is to utilize nanoengineered particles, functioning as drug-delivery systems or as antigens themselves. This article reviews the practical implementation of nanotechnology in cancer immunotherapy.
随着癌细胞免疫监视和免疫逃逸机制研究的进展，癌症免疫疗法在治疗癌症方面显示出良好的效果，疗效确切且毒性较小。由于存在脱靶效应，将疫苗、佐剂或抗体直接递送至肿瘤部位的方法正受到广泛关注。一种有效的替代方法是利用纳米工程颗粒，其可作为药物递送系统或自身作为抗原发挥作用。本文综述了纳米技术在癌症免疫疗法中的实际应用。
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