Deshayes Stephanie, Gref Ruxandra
Department of Bioengineering, University of California, Los Angeles, CA 90095, USA.
Nanomedicine (Lond). 2014 Jul;9(10):1545-64. doi: 10.2217/nnm.14.67.
Nanotechnology has the potential to revolutionize drug delivery, but still faces some limitations. One of the main issues regarding conventional nanoparticles is their poor drug-loading and their early burst release. Thus, to overcome these problems, researchers have taken advantage of the host-guest interactions that drive some assemblies to form cage molecules able to strongly entrap their cargo and design new nanocarriers called cage nanoparticles. These systems can be classified into two categories: bioinspired nanosystems such as virus-like particles, ferritin, small heat shock protein: and synthetic host-guest supramolecular systems that require engineering to actually form supramolecular nanoassemblies. This review will highlight the recent advances in cage nanoparticles for drug delivery with a particular focus on their biomedical applications.
纳米技术有潜力彻底改变药物递送方式，但仍面临一些局限性。传统纳米颗粒的一个主要问题是其药物负载量低以及早期突释现象。因此，为克服这些问题，研究人员利用了主客体相互作用，这种相互作用促使一些组装体形成能够强烈包裹其货物的笼状分子，并设计了名为笼状纳米颗粒的新型纳米载体。这些系统可分为两类：受生物启发的纳米系统，如病毒样颗粒、铁蛋白、小分子热休克蛋白；以及需要进行工程设计才能实际形成超分子纳米组装体的合成主客体超分子系统。本综述将重点介绍笼状纳米颗粒在药物递送方面的最新进展，特别关注其生物医学应用。
