Kotla Nikhil Kumar, Dutta Priyata, Parimi Sanjana, Das Nupur K
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Metabolites. 2022 Jun 30;12(7):609. doi: 10.3390/metabo12070609.
Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc. In mammals, sufficient dietary acquisition is critical for fulfilling the systemic iron requirement. New questions are emerging about whether and how cellular iron transport pathways integrate with the iron storage mechanism. Ferritin is the intracellular iron storage protein that stores surplus iron after all the cellular needs are fulfilled and releases it in the face of an acute demand. Currently, there is a surge in interest in ferritin research after the discovery of novel pathways like ferritinophagy and ferroptosis. This review emphasizes the most recent ferritin-related discoveries and their impact on systemic iron regulation.
全身铁稳态需要严格控制，因为铁缺乏和铁过量都会引发重大的全球健康问题，如缺铁性贫血、血色素沉着症等。在哺乳动物中，充足的膳食摄取对于满足全身铁需求至关重要。关于细胞铁转运途径是否以及如何与铁储存机制整合，新的问题正在出现。铁蛋白是细胞内的铁储存蛋白，在满足所有细胞需求后储存多余的铁，并在急性需求时释放它。目前，在发现铁蛋白自噬和铁死亡等新途径后，对铁蛋白研究的兴趣激增。本综述强调了与铁蛋白相关的最新发现及其对全身铁调节的影响。
