Butt Arshad Kamal, Hashemy Irfan
J Pak Med Assoc. 2014 Jul;64(7):751-7.
To determine the frequency of the use of proton-pump inhibitor therapy in patients with typical symptoms of gastroesophageal reflux disease and evaluate its risk factors.
The cross-sectional study was conducted between June 2010 and February 2011 across 10 cities of Pakistan. Adult patients giving a current history of typical gastroesophageal reflux disease symptoms were included. Information on patient demography, medical history, family history, prescription patterns, lifestyle factors and dietary habits were collected. SPSS 18 was used for statistical analysis and descriptive statistics were used for the analysis of categorical and continuous variables.
Of the 1010 patients enrolled, 954 (94.45%) formed the study population. Of them, 520 (54.5%) were men. The overall mean age was 41.9 +/- 12.5 years, and 439 (46%) had body mass index > or = 25 kg/m2. Further, 805 (84.4%) reported history of dyspepsia while 692 (72.5%) had gastroesophageal reflux disease during the preceding year. Family history of acid peptic disease was reported by 231 (24.2%) patients. Prior to consultation, 505 (52.9%) patients were on proton-pump inhibitors. Following consultation, 923 (96.8%) patients were prescribed proton-pump inhibitors, with omeprazole being the preferred choice in 577 (60.5%). Associated risk factors included regular use of nonsteroidal anti-inflammatory drugs in 355 (37.2%) and current smoking in 210 (22.0%). Consuming spicy meals was reported by 666 (70.0%).
Nearly half the patients with typical gastroesophageal reflux disease symptoms were overweight, and a majority consumed spicy meals. Proton-pump inhibitors were widely prescribed, and omeprazole was the preferred choice of drug.
确定有胃食管反流病典型症状的患者使用质子泵抑制剂治疗的频率，并评估其危险因素。
2010年6月至2011年2月在巴基斯坦的10个城市开展了这项横断面研究。纳入有当前胃食管反流病典型症状病史的成年患者。收集了患者人口统计学、病史、家族史、处方模式、生活方式因素和饮食习惯等信息。使用SPSS 18进行统计分析，分类变量和连续变量的分析采用描述性统计。
在纳入的1010例患者中，954例（94.45%）构成研究人群。其中，520例（54.5%）为男性。总体平均年龄为41.9±12.5岁，439例（46%）的体重指数≥25kg/m²。此外，805例（84.4%）报告有消化不良病史，692例（72.5%）在前一年有胃食管反流病。231例（24.2%）患者报告有酸性消化性疾病家族史。在咨询前，505例（52.9%）患者正在使用质子泵抑制剂。咨询后，923例（96.8%）患者被开具质子泵抑制剂，其中577例（60.5%）首选奥美拉唑。相关危险因素包括355例（37.2%）经常使用非甾体抗炎药和210例（22.0%）当前吸烟。666例（70.0%）报告食用辛辣食物。
近一半有胃食管反流病典型症状的患者超重，且大多数人食用辛辣食物。质子泵抑制剂被广泛处方，奥美拉唑是首选药物。
