Naghizadeh-Baghi Abbas, Mazani Mohammad, Shadman-Fard Ali, Nemati Ali
Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Fathemi Hospital, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Mater Sociomed. 2015 Feb;27(1):48-51. doi: 10.5455/msm.2014.27.48-51. Epub 2015 Feb 21.
The aim of this study was to investigate Punica granatum juice effects on oxidative stress in young healthy males during severe physical activity.
Our subjects were selected from healthy males at 18 - 24 years. They were enrolled and randomly distributed into control and supplemented groups. 240 ml of Punica granatum juice and tap water were given to supplement and control groups daily for two weeks, respectively. Fasting blood samples were taken at the starting and the end of two weeks of intervention. Subjects were given once severe physical activity and then fasting blood samples were taken. Fasting blood samples were used for testing of oxidative and antioxidative factors. Data were analyzed using descriptive statistical tests, paired samples t-test, and independent samples t-test.
The levels of arylesterase, superoxide dismutase, glutathione peroxidase and total antioxidant capacity after severe physical activity in supplement group were significantly increased (p<0.05), while the content of malondialdehyde showed a significantly decrease in comparison to control group (p<0.05).
Our findings indicate that regular intake of Punica granatum juice significantly modulates oxidative stress and thus protects against severe physical activity oxidative injury in young healthy males.
本研究旨在调查在剧烈体育活动期间，石榴汁对年轻健康男性氧化应激的影响。
我们的研究对象选自18至24岁的健康男性。他们被招募并随机分为对照组和补充组。补充组和对照组每天分别给予240毫升石榴汁和自来水，持续两周。在干预两周的开始和结束时采集空腹血样。让受试者进行一次剧烈体育活动，然后采集空腹血样。空腹血样用于检测氧化和抗氧化因子。数据采用描述性统计检验、配对样本t检验和独立样本t检验进行分析。
补充组在剧烈体育活动后，芳基酯酶、超氧化物歧化酶、谷胱甘肽过氧化物酶水平及总抗氧化能力显著升高（p<0.05），而丙二醛含量与对照组相比显著降低（p<0.05）。
我们的研究结果表明，定期饮用石榴汁可显著调节氧化应激，从而预防年轻健康男性在剧烈体育活动中的氧化损伤。
