Guo Changjiang, Wei Jingyu, Yang Jijun, Xu Jing, Pang Wei, Jiang Yugang
Department of Nutrition, Institute of Hygiene and Environmental Medicine, Tianjin, 300050, PR China.
Nutr Res. 2008 Feb;28(2):72-7. doi: 10.1016/j.nutres.2007.12.001.
In the present study, 26 elderly subjects were recruited and randomly divided into 2 groups, that is, apple (low in antioxidant capacity) and pomegranate (high in antioxidant capacity) groups, and 250 mL of juice was consumed daily for 4 weeks. Changes in plasma antioxidant capacity, activity of antioxidant enzymes, contents of ascorbic acid, vitamin E, reduced glutathione, malondialdehyde, oxidized low-density lipoprotein and carbonyls, and the degree of DNA damage in mononuclear blood cells were measured. Urine samples were collected for determination of 8-hydroxy-2'-deoxyguanosine content. Increased plasma antioxidant capacity and decreased plasma carbonyl content were demonstrated after daily consumption of pomegranate juice. In comparison, apple juice consumption presented a less significant effect on antioxidant function in elderly subjects. It is concluded that daily consumption of pomegranate juices is potentially better than apple juice in improving antioxidant function in the elderly. Because the plasma ascorbic acid, vitamin E, and reduced glutathione contents did not differ significantly between the 2 groups in this study, the phenolics may be the functional components contained in pomegranate juice that accounted for the observations.
在本研究中，招募了26名老年受试者并随机分为两组，即苹果组（抗氧化能力低）和石榴组（抗氧化能力高），每天饮用250毫升果汁，持续4周。测量血浆抗氧化能力、抗氧化酶活性、抗坏血酸、维生素E、还原型谷胱甘肽、丙二醛、氧化型低密度脂蛋白和羰基含量的变化，以及单核血细胞中DNA损伤程度。收集尿液样本以测定8-羟基-2'-脱氧鸟苷含量。每天饮用石榴汁后，血浆抗氧化能力增强，血浆羰基含量降低。相比之下，饮用苹果汁对老年受试者抗氧化功能的影响较小。得出的结论是，每天饮用石榴汁在改善老年人抗氧化功能方面可能比苹果汁更好。由于本研究中两组之间血浆抗坏血酸、维生素E和还原型谷胱甘肽含量没有显著差异，酚类物质可能是石榴汁中导致这些观察结果的功能成分。
