Pausova Zdenka, Paus Tomas, Abrahamowicz Michal, Bernard Manon, Gaudet Daniel, Leonard Gabriel, Peron Michel, Pike G Bruce, Richer Louis, Séguin Jean R, Veillette Suzanne
Hospital for Sick Children and Departments of Physiology and Nutritional Science.
Rotman Research Institute and Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada.
Int J Epidemiol. 2017 Apr 1;46(2):e19. doi: 10.1093/ije/dyw023.
The Saguenay Youth Study (SYS) is a two-generational study of adolescents and their parents (n = 1029 adolescents and 962 parents) aimed at investigating the aetiology, early stages and trans-generational trajectories of common cardiometabolic and brain diseases. The ultimate goal of this study is to identify effective means for increasing healthy life expectancy. The cohort was recruited from the genetic founder population of the Saguenay Lac St Jean region of Quebec, Canada. The participants underwent extensive (15-h) phenotyping, including an hour-long recording of beat-by-beat blood pressure, magnetic resonance imaging of the brain and abdomen, and serum lipidomic profiling with LC-ESI-MS. All participants have been genome-wide genotyped (with ∼ 8 M imputed single nucleotide polymorphisms) and a subset of them (144 adolescents and their 288 parents) has been genome-wide epityped (whole blood DNA, Infinium HumanMethylation450K BeadChip). These assessments are complemented by a detailed evaluation of each participant in a number of domains, including cognition, mental health and substance use, diet, physical activity and sleep, and family environment. The data collection took place during 2003-12 in adolescents (full) and their parents (partial), and during 2012-15 in parents (full). All data are available upon request.
萨格奈青少年研究（SYS）是一项针对青少年及其父母（1029名青少年和962名父母）的两代人研究，旨在调查常见心脏代谢疾病和脑部疾病的病因、早期阶段及跨代轨迹。本研究的最终目标是确定延长健康预期寿命的有效方法。该队列从加拿大魁北克萨格奈-圣让湖地区的遗传创始人群体中招募。参与者接受了广泛的（15小时）表型分析，包括逐搏血压的一小时记录、脑部和腹部的磁共振成像，以及使用液相色谱-电喷雾电离质谱法进行血清脂质组分析。所有参与者都进行了全基因组基因分型（约800万个推算单核苷酸多态性），其中一部分（144名青少年及其288名父母）进行了全基因组表观分型（全血DNA，Infinium HumanMethylation450K芯片）。这些评估还辅以对每位参与者在多个领域的详细评估，包括认知、心理健康和物质使用、饮食、身体活动和睡眠，以及家庭环境。数据收集于2003年至2012年期间在青少年（全部）及其父母（部分）中进行，于2012年至2015年期间在父母（全部）中进行。所有数据可应要求提供。
