Ryan Meghann, Kochunov Peter, Rowland Laura M, Mitchell Braxton D, Wijtenburg S Andrea, Fieremans Els, Veraart Jelle, Novikov Dmitry S, Du Xiaoming, Adhikari Bhim, Fisseha Feven, Bruce Heather, Chiappelli Joshua, Sampath Hemalatha, Ament Seth, O'Connell Jeffrey, Shuldiner Alan R, Hong L Elliot
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Obesity (Silver Spring). 2017 Nov;25(11):1876-1880. doi: 10.1002/oby.21946. Epub 2017 Aug 20.
To assess the association between peripheral lipid/fat profiles and cerebral gray matter (GM) and white matter (WM) in healthy Old Order Amish (OOA).
Blood lipids, abdominal adiposity, liver lipid contents, and cerebral microstructure were assessed in OOA (N = 64, 31 males/33 females, ages 18-77). Orthogonal factors were extracted from lipid and imaging adiposity measures. GM assessment used the Human Connectome Project protocol to measure whole-brain average cortical thickness. Diffusion-weighted imaging was used to derive WM fractional anisotropy and kurtosis anisotropy measurements.
Lipid/fat measures were captured by three orthogonal factors explaining 80% of the variance. Factor one loaded on cholesterol and/or low-density lipoprotein cholesterol measurements; factor two loaded on triglyceride/liver measurements; and factor three loaded on abdominal fat measurements. A two-stage regression including age/sex (first stage) and the three factors (second stage) examined the peripheral lipid/fat effects. Factors two and three significantly contributed to WM measures after Bonferroni corrections (P < 0.007). No factor significantly contributed to GM. Blood pressure (BP) inclusion did not meaningfully alter the lipid/fat-WM relationship.
Peripheral lipid/fat indicators were significantly and negatively associated with cerebral WM rather than with GM, independent of age and BP level. Dissecting the fat/lipid components contributing to different brain imaging parameters may open a new understanding of the body-brain connection through lipid metabolism.
评估健康的旧秩序阿米什人（OOA）外周脂质/脂肪谱与脑灰质（GM）和白质（WM）之间的关联。
对OOA（N = 64，31名男性/33名女性，年龄18 - 77岁）进行血脂、腹部肥胖、肝脏脂质含量和脑微观结构评估。从脂质和成像肥胖测量中提取正交因子。GM评估采用人类连接体计划方案测量全脑平均皮质厚度。扩散加权成像用于得出WM分数各向异性和峰度各向异性测量值。
脂质/脂肪测量由三个正交因子捕获，解释了80%的方差。因子一加载在胆固醇和/或低密度脂蛋白胆固醇测量上；因子二加载在甘油三酯/肝脏测量上；因子三加载在腹部脂肪测量上。一个包括年龄/性别（第一阶段）和三个因子（第二阶段）的两阶段回归分析了外周脂质/脂肪的影响。经Bonferroni校正后，因子二和因子三对WM测量有显著贡献（P < 0.007）。没有因子对GM有显著贡献。纳入血压（BP）并没有显著改变脂质/脂肪与WM的关系。
外周脂质/脂肪指标与脑WM显著负相关，而非与GM，且独立于年龄和BP水平。剖析导致不同脑成像参数的脂肪/脂质成分可能会通过脂质代谢开启对身体与大脑联系的新认识。
