Liu Qian, Song Bing
Cardiff Institute of Tissue Engineering & Repair, School of Dentistry, College of Biomedical & Life Sciences, Cardiff University, Cardiff, CF14 4XY, United Kingdom.
Cardiff Institute of Tissue Engineering & Repair, School of Dentistry, College of Biomedical & Life Sciences, Cardiff University, Cardiff, CF14 4XY, United Kingdom.
Int J Biochem Cell Biol. 2014 Oct;55:264-8. doi: 10.1016/j.biocel.2014.09.014. Epub 2014 Sep 22.
Physiological electric field (EF) is a potent guidance cue for many physiological development and pathological conditions. The EF induced cellular responses such as migration and proliferation, are considered to be regulated by multiple signaling pathways in a coordinated way. Unlike the signaling transduction regulating the cellular responses toward chemical gradients, the signaling network involved in electric stimulation shows a unique manner, combining the regulation of ion channels, membrane receptors and associated intracellular signaling pathways. This review shall discuss the cellular responses in EF, and summarize the primary signaling network activated during the EF-induced cellular response.
生理电场（EF）是许多生理发育和病理状况的一种强大的引导线索。EF诱导的细胞反应，如迁移和增殖，被认为是由多种信号通路以协调的方式调节的。与调节细胞对化学梯度反应的信号转导不同，参与电刺激的信号网络呈现出独特的方式，它结合了离子通道、膜受体及相关细胞内信号通路的调节。本综述将讨论EF中的细胞反应，并总结在EF诱导的细胞反应过程中激活的主要信号网络。
