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电刺激疗法——致力于完美的整形修复。

Electrical Stimulation Therapy - Dedicated to the Perfect Plastic Repair.

作者信息

Deng Kexin, Luo Ruizeng, Chen Ying, Liu Xiaoqiang, Xi Yuanyin, Usman Muhammad, Jiang Xupin, Li Zhou, Zhang Jiaping

机构信息

Department of Plastic Surgery, State Key Laboratory of Trauma and Chemical Poisoning, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.

出版信息

Adv Sci (Weinh). 2025 Jun;12(24):e2409884. doi: 10.1002/advs.202409884. Epub 2024 Dec 16.

Abstract

Tissue repair and reconstruction are a clinical difficulty. Bioelectricity has been identified as a critical factor in supporting tissue and cell viability during the repair process, presenting substantial potential for clinical application. This review delves into various sources of electrical stimulation and identifies appropriate electrode materials for clinical use. It also highlights the biological mechanisms of electrical stimulation at both the subcellular and cellular levels, elucidating how these interactions facilitate the repair and regeneration processes across different organs. Moreover, specific electrode materials and stimulation sources are outlined, detailing their impact on cellular activity. The future development trends are projected from two perspectives: the optimization of equipment performance and the fulfillment of clinical demands, focusing on the feasibility, safety, and cost-effectiveness of technologies.

摘要

组织修复与重建是一项临床难题。生物电已被确认为在修复过程中支持组织和细胞活力的关键因素,具有巨大的临床应用潜力。本综述深入探讨了电刺激的各种来源,并确定了适用于临床的电极材料。它还突出了亚细胞和细胞水平上电刺激的生物学机制,阐明了这些相互作用如何促进不同器官的修复和再生过程。此外,概述了特定的电极材料和刺激源,详细说明了它们对细胞活性的影响。从设备性能优化和临床需求满足两个角度预测了未来的发展趋势,重点关注技术的可行性、安全性和成本效益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d387/12199585/c446b1bcabfb/ADVS-12-2409884-g014.jpg

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