Regan F H, Hockenhull J, Pritchard J C, Waterman-Pearson A E, Whay H R
School of Veterinary Sciences, University of Bristol, UK.
Animals in International Development, North Somerset, UK.
Equine Vet J. 2016 Jan;48(1):33-8. doi: 10.1111/evj.12356. Epub 2015 Jan 20.
To identify pain-related behaviour in working donkeys in order to assist their owners and veterinarians to recognise and manage pain.
To identify general and specific behaviours associated with pain or its relief using a trial with the nonsteroidal anti-inflammatory drug meloxicam (Metacam).
Observer-blinded, placebo-controlled trial.
Forty adult male working donkeys with common clinical abnormalities were randomly assigned to receive either a single loading dose of meloxicam (1.2 mg/kg bwt per os; n = 20) or a placebo (30 mg honey/250 ml water per os; n = 20). Observation of postural and event behaviours was undertaken at 2 pretreatment time points followed by 4 post treatment time points, using scan (instantaneous) and focal sampling.
In comparison to pretreatment baselines, donkeys receiving meloxicam were more alert post treatment than the placebo group. They were observed lying down less frequently (P = 0.007), with their eyes closed less frequently (P = 0.04) and having a high head carriage more frequently (P = 0.02). Dozing behaviour decreased after meloxicam compared with the pretreatment baseline (P = 0.03). Donkeys given meloxicam also showed more interest in their environment, turning to look at environmental stimuli more frequently (P = 0.05) than those in the placebo group post treatment. Neither the meloxicam nor the placebo group showed a significant post treatment improvement in lameness scores.
Working donkeys receiving meloxicam were more active and alert compared with their pretreatment behaviour, confirming the potential value of nonsteroidal anti-inflammatory drugs in identifying behaviours indicative of pain in working donkeys. Behavioural assessment of pain in working donkeys in field clinic conditions will enable veterinary staff and owners to identify welfare issues promptly and monitor response to analgesia. The Summary is available in Chinese--see Supporting information.
识别劳作中驴的疼痛相关行为，以帮助其主人和兽医识别并处理疼痛。
通过使用非甾体抗炎药美洛昔康（Metacam）进行试验，识别与疼痛或疼痛缓解相关的一般和特定行为。
观察者盲法、安慰剂对照试验。
将40头患有常见临床异常的成年雄性劳作驴随机分为两组，一组接受单次负荷剂量的美洛昔康（1.2毫克/千克体重，口服；n = 20），另一组接受安慰剂（30毫克蜂蜜/250毫升水，口服；n = 20）。在2个预处理时间点之后，通过扫描（即时）和焦点取样对姿势和事件行为进行观察，共进行4个治疗后时间点的观察。
与预处理基线相比，接受美洛昔康治疗的驴在治疗后比安慰剂组更警觉。观察到它们躺下的频率更低（P = 0.007），闭眼的频率更低（P = 0.04），抬头的频率更高（P = 0.02）。与预处理基线相比，美洛昔康治疗后打盹行为减少（P = 0.03）。接受美洛昔康治疗的驴在治疗后对周围环境也表现出更大兴趣，转头查看环境刺激的频率比安慰剂组更高（P = 0.05）。美洛昔康组和安慰剂组在治疗后跛行评分均未显示出显著改善。
与预处理行为相比，接受美洛昔康治疗的劳作驴更加活跃和警觉，证实了非甾体抗炎药在识别劳作驴疼痛相关行为方面的潜在价值。在现场临床条件下对劳作驴的疼痛进行行为评估，将使兽医工作人员和主人能够及时识别福利问题并监测镇痛反应。中文摘要见补充信息。
