Tang Hsin-Yi, Vitiello Michael V, Perlis Michael, Mao Jun James, Riegel Barbara
Health Science Center, School of Nursing, University of Washington, 1959 NE Pacific St., Box 357263, Seattle, WA, 98195-7263, USA,
Appl Psychophysiol Biofeedback. 2014 Dec;39(3-4):219-25. doi: 10.1007/s10484-014-9263-8.
This pilot study tested the efficacy of an audio-visual stimulation (AVS) program for the promotion of sleep in individuals with chronic pain. Insomnia and chronic pain are common comorbid conditions and their relationship has been viewed as bidirectional. Recent studies suggest a relatively dominant role of sleep in this dyad. The premise of this pilot study was that AVS enhances low frequency while reducing high frequency brain activity resulting in decreased hyperarousal and improved sleep with potential consequent reduction in pain. We conducted a pilot intervention study of AVS using a pre-post design. Participants self-administered a 30-min AVS program nightly at bedtime for 1 month. Sleep and pain were assessed at baseline and at the conclusion of the 4-week intervention phase. Nine adults (mean age 33 ± 15.8 years; female, 89 %) completed the study. After using the AVS device for 4 weeks, significant improvement was seen in reported insomnia (ISI, p = 0.003), pain severity (BPI, p = 0.005), and pain interference with functioning (BPI, p = 0.001). Large effect sizes (Partial η(2) 0.20-0.94) (Cohen's d 0.44-1.45) were observed. The results of this pilot study suggest that the AVS program may be efficacious in decreasing both insomnia and pain symptoms. In order to better assess the efficacy of AVS for sleep promotion and possible pain reduction, more definitive randomized controlled trials will be needed. These should include appropriate sample sizes, objective measures of sleep and pain, and longitudinal follow-up.
这项试点研究测试了视听刺激(AVS)程序对促进慢性疼痛患者睡眠的疗效。失眠和慢性疼痛是常见的共病情况,它们之间的关系被认为是双向的。最近的研究表明,在这种二元关系中,睡眠起着相对主导的作用。这项试点研究的前提是,AVS可增强低频脑活动,同时减少高频脑活动,从而减少过度觉醒,改善睡眠,并可能随之减轻疼痛。我们采用前后设计对AVS进行了一项试点干预研究。参与者在每晚就寝时自行进行30分钟的AVS程序,为期1个月。在基线和4周干预阶段结束时评估睡眠和疼痛情况。9名成年人(平均年龄33±15.8岁;女性占89%)完成了研究。使用AVS设备4周后,报告的失眠(ISI,p = 0.003)、疼痛严重程度(BPI,p = 0.005)和疼痛对功能的干扰(BPI,p = 0.001)均有显著改善。观察到较大的效应量(偏η² 0.20 - 0.94)(科恩d值0.44 - 1.45)。这项试点研究的结果表明,AVS程序可能对减轻失眠和疼痛症状有效。为了更好地评估AVS促进睡眠和可能减轻疼痛的疗效,需要进行更明确的随机对照试验。这些试验应包括适当的样本量、睡眠和疼痛的客观测量以及纵向随访。