Lande K, Os I, Kjeldsen S E, Westheim A, Hjermann I, Eide I, Gjesdal K
Department of Internal Medicine, Oslo University Medical School, Ullevaal Hospital, Norway.
Scand J Clin Lab Invest. 1989 Jun;49(4):307-15. doi: 10.3109/00365518909089102.
To examine the effect of dopamine on in vivo platelet function and a possible platelet contribution to the clearance of dopamine we measured platelet count, platelet size and plasma concentration of the platelet specific protein beta-thromboglobulin (BTG) in groups of 40 year old untreated hypertensive and normotensive men. One hypertensive (n = 10) and one normotensive (n = 10) group received dopamine infusion at doses from 0.5 to 2.0 micrograms/kg/min which increased plasma dopamine 100-fold from baseline. Two other groups of hypertensive (n = 10) and normotensive (n = 11) subjects received 10 mg of the dopamine antagonist metoclopramide intravenously, upon which serum prolactin concentration increased 10-fold. No significant effect on platelet function in any group was observed during these interventions. Platelet phenol-sulphotransferase may contribute to dopamine conjugation. However, the selected platelet parameters correlated only weakly with dopamine kinetics during the infusion. Neither dopamine nor a dopamine antagonist altered the selected platelet parameters, nor did these parameters influence the clearance of dopamine during a short-lasting pharmacological infusion.
为了研究多巴胺对体内血小板功能的影响以及血小板对多巴胺清除可能产生的作用，我们对40岁未接受治疗的高血压男性和血压正常男性分组测量了血小板计数、血小板大小以及血小板特异性蛋白β-血小板球蛋白（BTG）的血浆浓度。一组高血压患者（n = 10）和一组血压正常者（n = 10）接受了剂量为0.5至2.0微克/千克/分钟的多巴胺输注，这使血浆多巴胺浓度从基线水平增加了100倍。另外两组高血压患者（n = 10）和血压正常者（n = 11）静脉注射了10毫克多巴胺拮抗剂甲氧氯普胺，随后血清催乳素浓度增加了10倍。在这些干预过程中，未观察到对任何一组血小板功能有显著影响。血小板酚磺基转移酶可能有助于多巴胺结合。然而，在输注过程中，所选血小板参数与多巴胺动力学的相关性较弱。多巴胺和多巴胺拮抗剂均未改变所选血小板参数，在短期药理输注过程中这些参数也未影响多巴胺的清除。
